http://www.medindex.cz/ zdravotnictví Fri, 18 May 2012 18:55:16 GMT Medindex - Databáze a hodnocení lékařů. Prostřednictvím prezentace objektivních a relevantních údajů o poskytovatelích zdravotní služby v České republice se Medindex o.p.s. snaží přispět ke zprůhlednění práce lékařů a zdravotnických zařízení. K tomuto cíli směřuje i zavedení odborného a pacientského hodnocení lékařů. http://www.medindex.cz/images/logo-medindex.jpg http://www.medindex.cz/ http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-390 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-392 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-394 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-396 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-398 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-400 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-402 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-405 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-406 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-411 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-413 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-415 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-417 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-420 Thu, 31 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-432 Articles in this issue: RESEARCH: The effectiveness of SPARX, a computerised self help intervention for adolescents seeking help for depression: randomised controlled non-inferiority trial. Vaccination against pandemic A/H1N1 2009 influenza in pregnancy and risk of fetal death: cohort study in Denmark. Long term outcomes in men screened for abdominal aortic aneurysm: prospective cohort study. Outcomes of elective induction of labour compared with expectant management: population based study. Sat, 19 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-434 Articles in this issue: Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. REVIEW: Scaling up interventions to achieve global tuberculosis control: progress and new developments. Sat, 19 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-437 Articles in this issue: REVIEWS: Ethnicity and Conflict: Theory and Facts. Modeling Armed Conflicts. Life Without War. PERSPECTIVES: Adapting to a Multicultural Future. Climate Change and Violent Conflict. The Antiquity of Empathy. Religious and Sacred Imperatives in Human Conflict. Fri, 18 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-438 Articles in this issue: Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm. Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy. Azithromycin and the Risk of Cardiovascular Death. Association of Coffee Drinking with Total and Cause-Specific Mortality. Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia. CLINICAL PRACTICE: Secondary Prevention after Ischemic Stroke or Transient Ischemic Attack. Fri, 18 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-431 Articles in this issue: BLOOD WORK: Atypical mycobacteria in a patient with HIV and ITP. CLINICAL TRIALS AND OBSERVATIONS: Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma. Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia. IMMUNOBIOLOGY: Regulation of Th1/Th2 polarization by tissue inhibitor of metalloproteinase-3 via modulating dendritic cells. TROMBOSIS AND HEMOSTASIS: t-PA–specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes Thu, 17 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-435 Articles in this issue: Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Structure of the human κ-opioid receptor in complex with JDTic. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. NEWS & VIEWS: Planetary science: Martian sand blowing in the wind. Structural biology: How opioid drugs bind to receptors. Genetics: Fish heads and human disease. Atomic physics: Electrons get real. Neuroscience: Brain-controlled robot grabs attention. Earth science: Geomagnetism under scrutiny. Thu, 17 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-433 Articles in this issue: ORIGINAL CONTRIBUTION: Effect of a Multifaceted Intervention on Use of Evidence-Based Therapies in Patients With Acute Coronary Syndromes in Brazil: The BRIDGE-ACS Randomized Trial. Effects of Prenatal Micronutrient and Early Food Supplementation on Maternal Hemoglobin, Birth Weight, and Infant Mortality Among Children in Bangladesh: The MINIMat Randomized Trial. HIV Development Assistance and Adult Mortality in Africa. Wed, 16 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-436 Articles in this issue: Genetics: Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber’s hereditary optic neuropathy in a mouse model. Immunology: microRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination. Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells. Medical Sciences: Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition. Common patterns and disease-related signatures in tuberculosis and sarcoidosis. Tue, 15 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-424 Articles in this issue: RESEARCH: Risk of cardiovascular serious adverse events associated with varenicline use for tobacco cessation: systematic review and meta-analysis. Effects of multidisciplinary team working on breast cancer survival: retrospective, comparative, interventional cohort study of 13 722 women. Derivation and validation of a risk adjustment model for predicting seven day mortality in emergency medical admissions: mixed prospective and retrospective cohort study. Health, employment, and economic change, 1973-2009: repeated cross sectional study. Sat, 12 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-426 Articles in this issue: Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial. Cervical pessary in pregnant women with a short cervix (PECEP): an open-label randomised controlled trial. Cancer mortality in India: a nationally representative survey. Complications of first-trimester abortion by vacuum aspiration after cervical preparation with and without misoprostol: a multicentre randomised trial. Sat, 12 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-425 Articles in this issue: ORIGINAL CONTRIBUTIONS: Comparison of Risk Prediction Using the CKD-EPI Equation and the MDRD Study Equation for Estimated Glomerular Filtration Rate. Out-of-Hospital Administration of Intravenous Glucose-Insulin-Potassium in Patients With Suspected Acute Coronary Syndromes: The IMMEDIATE Randomized Controlled Trial. CLINICAL REVIEW: Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea: A Systematic Review and Meta-analysis. Fri, 11 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-429 Articles in this issue: PERSPECTIVES: Cell Biology: FGF21 Takes a Fat Bite. Geophysics: Understanding Earthquakes. Stuctural Biology: PARP-1 Activation—Bringing the Pieces Together. Physics: Intertwining Electron Tunneling with Light. Molecular Biology: RNA Plays Meiotic Matchmaker. Climate change: The Ice Age Carbon Puzzle. Fri, 11 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-423 Articles in this issue: PERSPECTIVES: Monoclonal B-cell lymphocytosis: right track or red herring?. REVIEW ARTICLE: Quantitative modeling of chronic myeloid leukemia: insights from radiobiology. CLINICAL TRIALS AND OBSERVATIONS: Progression in smoldering Waldenström macroglobulinemia: long-term results. GENE THERAPY: Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome. IMMUNOBIOLOGY: Redefining interferon-producing killer dendritic cells as a novel intermediate in NK-cell differentiation. The tyrosine phosphatase SHP-1 dampens murine Th17 development. TRANSPLANTATION: Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease. Thu, 10 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-427 Articles in this issue: NEWS & VIEWS: Cardiovascular Biology: Escaped DNA inflames the heart. Stem Cells: One step closer to gut repair. Black holes: Star ripped to shreds. Materials science: Cracks tamed. Climate science: A grip on ice-age ocean circulation. ARTICLES: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Thu, 10 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-430 Articles in this issue: ORIGINAL ARTICLES: Continuous Lenalidomide Treatment for Newly Diagnosed Multiple Myeloma. Lenalidomide after Stem-Cell Transplantation for Multiple Myeloma. Outcomes of PCI at Hospitals with or without On-Site Cardiac Surgery. Reproductive Technologies and the Risk of Birth Defects. REVIEW ARTICLE: Current Concepts: Percutaneous Coronary Interventions without On-Site Cardiac Surgical Backup. Thu, 10 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-428 Articles in this issue: PERSPECTIVE: Transformational adaptation when incremental adaptations to climate change are insufficient. Chemistry: Probing the stability of nonglycosylated wild-type erythropoietin protein via reiterative alanine ligations. Computational design of a protein crystal. Enviromental Sciences: Committed carbon emissions, deforestation, and community land conversion from oil palm plantation expansion in West Kalimantan, Indonesia. Cell Biology: Nonthermal ATP-dependent fluctuations contribute to the in vivo motion of chromosomal loci. Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA. Tue, 08 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-395 Articles in this issue: RESEARCH: Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. Total hip arthoplasty versus resurfacing arthroplasty in the treatment of patients with arthritis of the hip joint: single centre, parallel group, assessor blinded, randomised controlled trial. Diagnostic value of single complete compression ultrasonography in pregnant and postpartum women with suspected deep vein thrombosis: prospective study. Bullying victimisation and risk of self harm in early adolescence: longitudinal cohort study. Sat, 05 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-404 Articles in this issue: Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial. Conventional combination treatment versus biological treatment in methotrexate-refractory early rheumatoid arthritis: 2 year follow-up of the randomised, non-blinded, parallel-group Swefot trial. Active management of the third stage of labour with and without controlled cord traction: a randomised, controlled, non-inferiority trial. CLINICAL PICTURE: Palmoplantar pustulosis and chest pain. Sat, 05 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-391 Článek v tomto čísle: "Basophils and antigen presentation: of mice and not men?": Je všeobecně známo, že dendritické buňky jsou neúčinnějšími antigeny prezentující se buňkami (APC), co se týče jejich schopnosti stimulovat naivní T-lymfocyty. Další APC, například B-lymfocyty a makrofágy, tuto schopnost nemají. V minulosti bylo na myším modelu dokázáno, že bazofil nejsou pouze prozánětlivými cytokiny (IL-4), ale jsou schopné fungovat jako APC. T-lymfocyty stimulované IL-4 se vyvíjejí v Th2 lymfocyty. Je jen otázkou, zda-li by stejné mechanismy mohly fungovat i u člověka. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-397 Articles in this issue: Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries. The Poly(A)-Binding Protein Nuclear 1 Suppresses Alternative Cleavage and Polyadenylation Sites. Nucleation and Transport Organize Microtubules in Metaphase Spindles. Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic Laminopathies. Hikeshi, a Nuclear Import Carrier for Hsp70s, Protects Cells from Heat Shock-Induced Nuclear Damage. The Transcriptional and Epigenomic Foundations of Ground State Pluripotency. A System of Repressor Gradients Spatially Organizes the Boundaries of Bicoid-Dependent Target Genes. A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-399 Articles in this issue: Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation. Thyroid Hormone Signaling Acts as a Neurogenic Switch by Repressing Sox2 in the Adult Neural Stem Cell Niche. Mesenchymal-Stem-Cell-Induced Immunoregulation Involves FAS-Ligand-/FAS-Mediated T Cell Apoptosis. Background Mutations in Parental Cells Account for Most of the Genetic Heterogeneity of Induced Pluripotent Stem Cells. Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-401 Articles in this issue: ORIGINAL CONTRIBUTIONS: Effect of Fish Oil Supplementation on Graft Patency and Cardiovascular Events Among Patients With New Synthetic Arteriovenous Hemodialysis Grafts: A Randomized Controlled Trial. Association Between Treatment With Brachytherapy vs Whole-Breast Irradiation and Subsequent Mastectomy, Complications, and Survival Among Older Women With Invasive Breast Cancer. CLINICAL CROSSROADS: Diagnosis and Treatment of Depression in Adults With Comorbid Medical Conditions: A 52-Year-Old Man With Depression. MEDICAL NEWS & PERSPECTIVES: “Doc Fix” Saves Medicare Payments Again But Takes the Funds From Public Health. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-403 Articles in this issue: Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling. Cell Biology: The Double-Stranded RNA Analogue Polyinosinic-Polycytidylic Acid Induces Keratinocyte Pyroptosis and Release of IL-36γ. Clinical Research: A Community-Based Study of Nucleotide Excision Repair Polymorphisms in Relation to the Risk of Non-Melanoma Skin Cancer. Genetics: Natural Gene Therapy May Occur in All Patients with Generalized Non-Herlitz Junctional Epidermolysis Bullosa with COL17A1 Mutations. Tumor Biology: MDM2 Inhibitor Nutlin-3a Induces Apoptosis and Senescence in Cutaneous T-Cell Lymphoma: Role of p53. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-408 Articles in this issue: NEWS & VIEWS: Photosensitivity syndrome brings to light a new transcription-coupled DNA repair cofactor. Cell type–specific eQTLs in the human immune system. ANALYSIS: Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. ARTICLES: Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Genetics of gene expression in primary immune cells identifies cell type–specific master regulators and roles of HLA alleles. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-409 Articles in this issue: REVIEWS: Intra-tumour heterogeneity: a looking glass for cancer?. The genetic architecture of multiple myeloma. From genes to drugs: targeted strategies for melanoma. PERSPECTIVES: Cancer imaging by optical coherence tomography: preclinical progress and clinical potential. Screening for cancer with molecular markers: progress comes with potential problems. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-410 Articles in this issue: REVIEWS: Regulation and function of mTOR signalling in T cell fate decisions. Fine-tuning of dendritic cell biology by the TNF superfamily. Revisiting the role of the granuloma in tuberculosis. Interferon-inducible effector mechanisms in cell-autonomous immunity. Multipotent mesenchymal stromal cells and the innate immune system. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-412 Articles in this issue: Chemistry: Octahydriodo diborane (B2H8) and its protonated cations containing five-, six-, and seven-coordinate boron atoms. Physics: Coupling actin flow, adhesion, and morphology in a computational cell motility model. The inexorable resistance of inertia determines the initial regime of drop coalescence. Anthropology: Representation of stable social dominance relations by human infants. Biochemistry: A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence. Cell Biology: Coupling actin flow, adhesion, and morphology in a computational cell motility model. Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-414 Articles in this issue: NEWS & VIEWS: Budget Cap Could Gut Next Big Fermilab Project. One H5N1 Paper Finally Goes to Press; Second Greenlighted. PERSPECTIVES: Cell Biology: Superresolution Subspace Signaling. Physics: The Impact of Ionic Frustration on Electronic Order. Planetary Science: A Dynamic Twist in the Tail. Climate Change: Regional Sea-Level Projection. Ecology: Impacts of Biodiversity Loss. RESEARCH ARTICLE: Spin-Torque Switching with the Giant Spin Hall Effect of Tantalum. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-416 Articles in this issue: CLINICAL REVIEWS IN ALLERGY AND IMMUNOLOGY: A European perspective on immunotherapy for food allergies. MECHANISMS OF ALLERGIC DISEASES: Update on risk factors for food allergy. CURRENT PERSPECTIVES: The interpersonal and intrapersonal diversity of human-associated microbiota in key body sites. ASTHMA AND LOWER AIRWAY DISEASE: Genome-wide association study of lung function decline in adults with and without asthma. An ex vivo model of severe asthma using reconstituted human bronchial epithelium. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-419 Articles in this issue: Head-to-head comparison of accuracy of a rapid point-of-care HIV test with oral versus whole-blood specimens: a systematic review and meta-analysis. Intraoperative versus extended antimicrobial prophylaxis after gastric cancer surgery: a phase 3, open-label, randomised controlled, non-inferiority trial. Adverse effects of falciparum and vivax malaria and the safety of antimalarial treatment in early pregnancy: a population-based study. REVIEW: Hepatitis C virus clearance, reinfection, and persistence, with insights from studies of injecting drug users: towards a vaccine. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-421 Articles in this issue: ORIGINAL ARTICLES: Strategies of Radioiodine Ablation in Patients with Low-Risk Thyroid Cancer. Ablation with Low-Dose Radioiodine and Thyrotropin Alfa in Thyroid Cancer. Transcatheter Aortic-Valve Replacement for Inoperable Severe Aortic Stenosis. Registry of Transcatheter Aortic-Valve Implantation in High-Risk Patients. Fri, 04 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-393 Articles in this issue: CLINICAL TRIALS AND OBSERVATIONS: Identification of an active, well-tolerated dose of pralatrexate in patients with relapsed or refractory cutaneous T-cell lymphoma. Phase 2 study of rituximab-ABVD in classical Hodgkin lymphoma. GENE THERAPY: Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. TROMBOSIS AND HEMOSTASIS: Digestive vacuole of Plasmodium falciparum released during erythrocyte rupture dually activates complement and coagulation. VASCULAR BIOLOGY: Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). Thu, 03 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-407 Articles in this issue: NEWS & VIEWS: Solar System: Focus on ancient bombardment. Solid-state physics: Electrons do the split. Inorganic chemistry: Two-armed silicon. Drug discovery: Time in a bottle. Translational medicine: Double protection for weakened bones. Cancer biology: The director's cut. Planetary science: Mercury's mysteries start to unfold. ARTICLES: The translational landscape of mTOR signalling steers cancer initiation and metastasis. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Osteoprotection by semaphorin 3A. Thu, 03 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m05 jurnal-418 Articles in this issue: CELLULAR IMMUNOLOGY AND IMMUNE REGULATION: Integrin CD11b Negatively Regulates TLR9-Triggered Dendritic Cell Cross-Priming by Upregulating microRNA-146a. Runx1 Deficiency in CD4+ T Cells Causes Fatal Autoimmune Inflammatory Lung Disease Due to Spontaneous Hyperactivation of Cells. Wed, 02 May 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-306 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-328 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-329 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-331 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-333 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-336 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-337 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-339 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-341 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-344 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-350 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-351 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-353 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-355 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-357 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-359 Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-383 Articles in this issue: RESEARCH: Clinical and cost effectiveness of mobile phone supported self monitoring of asthma: multicentre randomised controlled trial. Effect of offering different therapy via an English national telephone quitline: randomised controlled trial. Lung protective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort study. Risk factors for mortality from imported falciparum malaria in the United Kingdom over 20 years: an observational study. Cost effectivenes of alternative planned places of birth in woman at low risk of complications: evidence from Birthplace in England national prospective cohort study. Angiotensin receptor blockers and risk of cancer: cohort study among people receiving antihypertensive drugs in UK General Practice Research Database. Mon, 30 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-385 Articles in this issue: Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial. Prevalence and risk of violence against adults with disabilities: a systematic review and meta-analysis of observational studies. Sat, 28 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-388 Articles in this issue: NEWS & ANALYSIS: Cancer: California Weighs Tobacco Tax Hike to Fund Research. Public health: Despite Gains, Malnutrition Among China's Rural Poor Sparks Concern. Global Warming: The Greenhouse Is Making the Water-Poor Even Poorer. NEWS FOCUS: Public Health: After a Successful Decade, Global Fight Appears Stalled. Evolution of language: Experiments Probe Language's Origins and Development. Where Time Goes Up and Down. Fri, 27 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-382 Articles in this issue: INSIDE BLOOD: Lymphocyte cytotoxicity: tug-of-war on microtubules. PERSPECTIVES: Acute myeloid leukemia in the real world: why population-based registries are needed. CLINICAL TRIALS AND OBSERVATIONS: Stroke With Transfusions Changing to Hydroxyurea (SWiTCH). Anti-CD20 (rituximab) therapy for anti–IFN-γ autoantibody–associated nontuberculous mycobacterial infection. IMMUNOBIOLOGY: Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. TROMBOSIS AND HEMOSTASIS: A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1. Thu, 26 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-386 Articles in this issue: Immunology: Allergy challenged. Quantum physics: Simulating magnetism. Protein engineering: Tighter ties that bind. Developmental biology: Heart under construction. Astrophysics: Stars throw their weight in old galaxies. ARTICLES: Multiple dynamic representations in the motor cortex during sensorimotor learning. Clonally dominant cardiomyocytes direct heart morphogenesis. Thu, 26 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-389 Articles in this issue: PERSPECTIVE: Making the Best of Hospital Pay for Performance. Controlling Health Care Spending — The Massachusetts Experiment. Financing Graduate Medical Education — Mounting Pressure for Reform. Moving Boundaries — The Nightingale Twins and Transplantation Science. ORIGINAL ARTICLES: Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes. Bariatric Surgery versus Conventional Medical Therapy for Type 2 Diabetes. Familial Diarrhea Syndrome Caused by an Activating GUCY2C Mutation. Low-Dose Abdominal CT for Evaluating Suspected Appendicitis. Thu, 26 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-384 Articles in this issue: ORIGINAL CONTRIBUTIONS: Effect of a Text Messaging Intervention on Influenza Vaccination in an Urban, Low-Income Pediatric and Adolescent Population: A Randomized Controlled Trial. Association Between Hospital Recognition for Nursing Excellence and Outcomes of Very Low-Birth-Weight Infants. Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure: The FOCUS-CCTRN Trial. Clinical Characteristics and Outcome of Infective Endocarditis Involving Implantable Cardiac Devices. Wed, 25 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-387 Articles in this issue: Engineering: Interfacial electronic effects in functional biolayers integrated into organic field-effect transistors. Enviromental Sciences: Greater focus needed on methane leakage from natural gas infrastructure. Biochemistry: ESR spectroscopy identifies inhibitory Cu2+ sites in a DNA-modifying enzyme to reveal determinants of catalytic specificity. Biophysics and Computational Biology: Mechanistic insight into the blocking of CO diffusion in [NiFe]-hydrogenase mutants through multiscale simulation. Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II. Tue, 24 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-375 Articles in this issue: RESEARCH: Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with metaanalyses and trial sequential analyses. Effect of implementation of Integrated Management of Neonatal and Childhood Illness (IMNCI) programme on neonatal and infant mortality: cluster randomised controlled trial. Impact of managed clinical networks on NHS specialist neonatal services in England: population based study. ANALYSIS: Colombia's response to healthcare crisis. Sat, 21 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-377 Articles in this issue: WORLD REPORT: Promising new era dawns for cystic fibrosis treatment. ARTICLES: Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Sat, 21 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-380 Článek v tomto čísle: Strach z nemoci citrusů, která byla objevena v Kalifornii, Texasu - Největší výskyt nemoci u citrusových rostlin byl zjištěn na Floridě v roce 2005. Huanglongbing neboli citrusová nemoc napadá ovoce, které postupně začne být kyselé a stromy během několika let zaniknou. Neexistuje žádný lék. Tato nemoc je přenášena malým drobným hmyzem. Tato bakteriální nemoc napadla už celou Floridu, zdvojnásobily se náklady na produkci citrusů. Co bude dál? Nemoc se objevila až v Kalifornii a Texasu, kteří jsou druhým a třetím největším výrobcem citrusů ve Spojených státech. Vědci doufají, že rychlé odstranění napadených stromů, zničení hmyzu, a dostatek času na rozvoj léčby nebo produkce odolnějších stromů nemoc potlačí. Fri, 20 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-374 Articles in this issue: INSIDE BLOOD: Applying the brakes to platelet activation. Improving on nature: redesigning ADAMTS13. PERSPECTIVES: Follicular lymphoma and the immune system: from pathogenesis to antibody therapy. HEMATOPOIESIS AND STEM CELLS: Angiotensin-converting enzyme (CD143) specifies emerging lympho-hematopoietic progenitors in the human embryo. IMMUNOBIOLOGY: Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice. TROMBOSIS AND HEMOSTASIS: The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells. Thu, 19 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-378 Articles in this issue: RESEARCH: NEWS & VIEWS: Sensory biology: Search for the compass needles. Geoscience: Fossil raindrops and ancient air. Quantum physics: Tunnelling across a nanowire. Electronics: Carbon nanotubes finally deliver. Circadian rhythms: No lazing on sunny afternoons. ARTICLES: A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. A unique regulatory phase of DNA methylation in the early mammalian embryo. The 2.8 Å crystal structure of the dynein motor domain. Thu, 19 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-381 Articles in this issue: ORIGINAL ARTICLES: Comparative Effectiveness of Revascularization Strategies. Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer. Off-Pump or On-Pump Coronary-Artery Bypass Grafting at 30 Days. REVIEW ARTICLE: Medical Progress: Alopecia Areata. IMAGES IN CLINICAL MEDICINE: Metastatic Inguinal Lymphadenopathy. Unilateral Dermatoheliosis. Thu, 19 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-376 Articles in this issue: ORIGINAL CONTRIBUTIONS: Carboplatin and Paclitaxel With vs Without Bevacizumab in Older Patients With Advanced Non–Small Cell Lung Cancer. Intensity-Modulated Radiation Therapy, Proton Therapy, or Conformal Radiation Therapy and Morbidity and Disease Control in Localized Prostate Cancer. Comparison of Long-term Survival After Open vs Endovascular Repair of Intact Abdominal Aortic Aneurysm Among Medicare Beneficiaries. Long-term Survival Following Partial vs Radical Nephrectomy Among Older Patients With Early-Stage Kidney Cancer. MEDICAL NEWS & PERSPECTIVES: US Can Draw Insight From Other Nations’ Experiences With Evidence-Based Medicine. Wed, 18 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-379 Articles in this issue: Chemistry: Shift-driven modulations of spin-echo signals. Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage. Engineering: Buckling-induced encapsulation of structured elastic shells under pressure. Biological Sciences: Evidence for a convergent slowdown in primate molecular rates and its implications for the timing of early primate evolution. Cell Biology: Role of the translationally controlled tumor protein in DNA damage sensing and repair. Correlative 3D superresolution fluorescence and electron microscopy reveal the relationship of mitochondrial nucleoids to membranes. Tue, 17 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-367 Articles in this issue: RESEARCH: Early detection and intervention evaluation for people at risk of psychosis: multisite randomised controlled trial. Implications of lowering threshold of plasma troponin concentration in diagnosis of myocardial infarction: cohort study. Association between low functional health literacy and mortality in older adults: longitudinal cohort study. Credibility of claims of subgroup effects in randomised controlled trials: systematic review. ANALYSIS: Challenges of drug resistance in the developing world. 3Rs for innovating novel antibiotics: sharing resources, risks, and reward. Sat, 14 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-369 Articles in this issue: WORLD REPORT: WHO plans new yaws eradication campaign. Not all that glitters: mercury poisoning in Colombia. ARTICLES: Stent thrombosis with drug-eluting and bare-metal stents: evidence from a comprehensive network meta-analysis. TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Effectiveness of internet-based cognitive behavioural treatment for adolescents with chronic fatigue syndrome (FITNET): a randomised controlled trial. Sat, 14 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-371 Článek v tomto čísle: "Lantibiotics from Geobacillus thermodenitrificans" - Lantibiotikum Nisin se více než 40 let používá jako účinný konzervační prostředek v boji proti napadnutí potravin patogeny. Navzdory tomuto úspěšnému použití je stabilita Nisinu omezena při pH 7. V tomto článku byl proto popsán analogový polypeptyd k Nisinu, kódovaný genomem termofilní bakterie thermodenitrificans Geobacillus (NG80-2). Tento podobný polypeptid byl nazván Geobacillin a byl získán heterologní expresí v Escherichia coli a jeho následným čištěním. Antimikrobiální spektrum Geobacillinu bylo obecně podobné z původců mastitidy skotu. Geobacillin prokazoval vyšší stabilitu v porovnání s Nisinem. Fri, 13 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-372 Articles in this issue: PERSPECTIVES: Neuroscience: Revitalizing Remyelination—the Answer Is Circulating. Wiping Drug Memories. Cell Biology: ESCRTing DNA at the Cleavage Site During Cytokinesis. Computer Science: Beyond Turing's Machines. Dusting Off the Turing Test. RESEARCH ARTICLE: A Fine-Scale Chimpanzee Genetic Map from Population Sequencing. Fri, 13 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-366 Articles in this issue: INSIDE BLOOD: Advancing the STATus of MPN pathogenesis. Overcoming “aspirin resistance” in MPN. GENE THERAPY: TCR affinity and specificity requirements for human regulatory T-cell function. IMMUNOBIOLOGY: Blood T-cell receptor diversity decreases during the course of HIV infection, but the potential for a diverse repertoire persists. TROMBOSIS AND HEMOSTASIS: Platelet Ca2+ responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca2+ stores. TRANSPLANTATION: Distinct but phenotypically heterogeneous human cell populations produce rapid recovery of platelets and neutrophils after transplantation. Thu, 12 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-370 Articles in this issue: NEWS & VIEWS: Climate science: Aerosols and Atlantic aberrations. Astrophysics: Fresh light on stardust. Gene expression: Running to stand still. Microbiology: Adaptation by target remodelling. ARTICLES: An elementary quantum network of single atoms in optical cavities. Teneurins instruct synaptic partner matching in an olfactory map. Structure of the mitotic checkpoint complex. Structural basis of ultraviolet-B perception by UVR8. Thu, 12 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-373 Articles in this issue: ORIGINAL ARTICLES: Outcomes after Induction Failure in Childhood Acute Lymphoblastic Leukemia. Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer. CT Angiography for Safe Discharge of Patients with Possible Acute Coronary Syndromes. Vorapaxar in the Secondary Prevention of Atherothrombotic Events. A Randomized Trial of Rectal Indomethacin to Prevent Post-ERCP Pancreatitis. Thu, 12 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-368 Articles in this issue: ORIGINAL CONTRIBUTIONS: Association of Major and Minor ECG Abnormalities With Coronary Heart Disease Events. Association of Treatment With Losartan vs Candesartan and Mortality Among Patients With Heart Failure. MEDICAL NEWS & PERSPECTIVES: AHA Statement Calls Attention to Risk of Peripheral Artery Disease in Women. Collaborative Effort Seeks to Curb Hospital Infections. Wed, 11 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-330 Articles in this issue: RESEARCH: White rice consumption and risk of type 2 diabetes: meta-analysis and systematic review. Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervival and vulvar disease: retrospective pooled analysi of trial data. Discontinuation of hormone replacement therapy after myocardial infarction and short term risk of adverse cardiovascular events: nationwide cohort study. Trends in cause specific mortality across occupations in Japanese men of working age during period of economic stagnation, 1980-2005: retrospective cohort study. Sat, 07 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-342 Articles in this issue: Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial. A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis. Effect of a cash transfer programme for schooling on prevalence of HIV and herpes simplex type 2 in Malawi: a cluster randomised trial. CLINICAL PICTURE: Homozygous familial hypercholesterolaemia. Sat, 07 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-332 Articles in this issue: ORIGINAL ARTICLES: Stem cells procurement: A risk-based approach to optimize autologous hematopoietic stem cell (HSC) collection with the use of plerixafor. Fludarabine as a risk factor for poor stem cell harvest, treatment-related MDS and AML in follicular lymphoma patients after autologous hematopoietic cell transplantation. Cord blood stem cells: Reduced-intensity hematopoietic cell transplantation in older patients with AML/MDS: umbilical cord blood is a feasible option for patients without HLA-matched sibling donors. Microbial issues: Voriconazole as primary antifungal prophylaxis in children undergoing allo-SCT. Fri, 06 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-334 Articles in this issue: Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State. COSA-1 Reveals Robust Homeostasis and Separable Licensing and Reinforcement Steps Governing Meiotic Crossovers. Coding Region Polyadenylation Generates a Truncated tRNA Synthetase that Counters Translation Repression. Membrane Fission Is Promoted by Insertion of Amphipathic Helices and Is Restricted by Crescent BAR Domains. Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion. THEORY: A Role for tRNA Modifications in Genome Structure and Codon Usage. Fri, 06 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-335 Articles in this issue: Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells. Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs. Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells. Human Embryonic Stem Cell-Derived GABA Neurons Correct Locomotion Deficits in Quinolinic Acid-Lesioned Mice. Fri, 06 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-345 Articles in this issue: Tumour immunology: Suppressing tumorigenic inflammation - "A paper uncovers a RAS–RAL GEF signalling pathway that activates AKT and RAL GTPases to promote survival and motility, and which is inhibited by the expression of the anti-inflammatory mediator TIPE2." Dendritic cell switch. Metastasis: Multitasking hyaluronic acid - "Inhibition of the hyaluronic acid scavenger receptor stabilin 2 blocks metastasis by preventing the attachment of tumour cells to lung endothelial cells." Metabolism: Unmasking an oncometabolite - "Mutant IDH genes that produce 2-hydroxyglutarate can influence cell transformation through effects on DNA and histone methylation and hypoxia inducible factors." Leukaemia: Adding e for survival - "Stromal cells take up and convert cystine into cysteine, which is used by chronic lymphocytic leukaemia cells to increase glutathione levels and to protect them against increased levels of reactive oxygen species and chemotherapeutic drugs." Immunotherapy: Combinations that work - "Two papers report preclinical data in support of combining targeted cancer therapies with immune stimulation mediated by CD137 activation." Fri, 06 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-346 Articles in this issue: NEWS & VIEWS: Gut insulin from Foxo1 loss. Genome-wide recombination in Chlamydia trachomatis. Vitamin C improves the quality of somatic cell reprogramming. ANALYSIS: Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. ARTICLES: Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all–iPS cell mice from terminally differentiated B cells. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Fri, 06 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-352 Articles in this issue: PERSPECTIVES: Immunology: Rebuilding the Thymus. Applied Physics: Stressing Ferroelectrics. Medicine: Irisin, Light my fire. RESEARCH ARTICLE: Population Genomics of Early Events in the Ecological Differentiation of Bacteria. Fri, 06 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-354 Articles in this issue: CLINICAL REVIEWS IN ALLERGY AND IMMUNOLOGY: An update on the role of human dendritic cells in patients with atopic dermatitis. MECHANISMS OF ALLERGIC DISEASES: The role of dendritic cells in asthma. ASTHMA AND LOWER AIRWAY DISEASE: Increased risk of pertussis in patients with asthma. Inhibition of angiogenesis by IL-32: Possible role in asthma. Airway epithelial cells from asthmatic children differentially express proremodeling factors. Fri, 06 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-356 Articles in this issue: CELLULAR IMMUNOLOGY AND IMMUNE REGULATION: Impaired IL-17 Signaling Pathway Contributes to the Increased Collagen Expression in Scleroderma Fibroblasts. CD16 Regulates TRIF-Dependent TLR4 Response in Human Monocytes and Their Subsets. Caspase-1 Has Both Proinflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1β and IL-18. Coordination between TLR9 Signaling in Macrophages and CD3 Signaling in T Cells Induces Robust Expression of IL-30. MOLECULAR AND STRUCTURAL IMMUNOLOGY: HLA-DQA2 and HLA-DQB2 Genes Are Specifically Expressed in Human Langerhans Cells and Encode a New HLA Class II Molecule. IMMUNOGENETICS: A Deficiency in Nucleoside Salvage Impairs Murine Lymphocyte Development, Homeostasis, and Survival. Fri, 06 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-358 Articles in this issue: Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial. A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebo-controlled, phase 2 trial. Effectiveness and cost-effectiveness of first BCG vaccination against tuberculosis in school-age children without previous tuberculin test (BCG-REVAC trial): a cluster-randomised trial. Effect of pretreatment HIV-1 drug resistance on immunological, virological, and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a multicentre cohort study. REVIEW: Optimisation of infection prevention and control in acute health care by use of behaviour change: a systematic review. CLINICAL PICTURE: Chronic unilateral conjunctivitis. Fri, 06 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-360 Articles in this issue: ORIGINAL ARTICLES: Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial. Oral Rivaroxaban for the Treatment of Symptomatic Pulmonary Embolism. Pyronaridine–Artesunate versus Mefloquine plus Artesunate for Malaria. Suicide and Cardiovascular Death after a Cancer Diagnosis. CLINICAL PRACTICE: Glycemic Management of Type 2 Diabetes Mellitus. CLINICAL PROBLEM - SOLVING: Skin deep. Fri, 06 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-327 Articles in this issue: INSIDE BLOOD: Evidence over hope for pregnancy complications. BLOOD WORK: Circulating mitotic figures in CMV-associated hydrops fetalis. CLINICAL TRIALS AND OBSERVATIONS: Heparin in pregnant women with previous placenta-mediated pregnancy complications: a prospective, randomized, multicenter, controlled clinical trial. The role of sex and weight on rituximab clearance and serum elimination half-life in elderly patients with DLBCL. THROMBOSIS AND HEMOSTASIS: Aβ delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin. VASCULAR BIOLOGY: ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Thu, 05 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-343 Articles in this issue: NEWS & VIEWS: Complex systems: Spotlight on mobility. Neuroscience: The symphony of choice. Cancer: Limitations of therapies exposed. Quantum optics: An entangled walk of photons. Climate change: A tale of two hemispheres. Atomic physics: An almost lightless laser. Genomics: Stickleback is the catch of the day. ARTICLES: Global warming preceded by increasing carbon dioxide concentrations during the last deglaciation. The genomic basis of adaptive evolution in threespine sticklebacks. Choice-specific sequences in parietal cortex during a virtual-navigation decision task. DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Thu, 05 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-307 Článek v tomto čísle: "Microbiota and dietary interactions - an update to the hygiene hypothesis": Předpokládá se, že dramatický nárůst výskytu alergií a astmatu v posledních letech může být spojeno s nižší kolonizací mikroorganismů, zejména v raném věku. I další faktory moderního životního stylu mohou mít vliv na rozvoj alergií (strava, fyzická aktivita atd.) Tento článek se zabývá potencionální rolí mikrobiálních metabolitů na regulaci imunitního systému, zejména na známé molekulární mechanismy, které se mohou zapojovat do interakcí mezi stravou, mikroby a ochranou před vznikem alergií a astmatu. "Cord blood immune status: predicting health or allergy?": Je známý vztah mezi imunitním stavem pupečníkové krve po porodu a pozdějším rozvojem alergií. Nyní se za hlavní faktory pro rozvoj alergií považují obsah cytokinů, počet regulačních T lymfocytů má vliv na zvýšenou hladinu totálního IgE. Také nižší hladina toll-like repetotu 5 (TLR5) má vliv na rozvoj atopické dermatitidy. Wed, 04 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-338 Articles in this issue: ORIGINAL CONTRIBUTIONS: Effect of Oxaliplatin, Fluorouracil, and Leucovorin With or Without Cetuximab on Survival Among Patients With Resected Stage III Colon Cancer: A Randomized Trial. Oral Fluoroquinolones and the Risk of Retinal Detachment. MEDICAL NEWS & PERSPECTIVES: Immunization Recommendations Expanded for Hepatitis B, HPV, Pertussis Vaccines. Medical Reserves Answer Call to Service. Wed, 04 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-348 Articles in this issue: Gene regulation: Clocking on for TLR9 - "TLR9 expression levels and immune responsiveness are under circadian control." B cells: An innate talent uncovered - "Innate functions of B cells are important for antiviral immunity." Autoimmunity: Fortune tellers - "A new MRI technique can accurately predict diabetes development in NOD mice." T cell memory: Skin-deep memory - "Skin-resident effector memory CD8+ T cells provide long-lasting immune protection in the skin." T cell development: Tonsils turn out T cells development - Tonsils turn out T cells too - "A stepwise programme of T cell development in human tonsils." Wed, 04 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-349 Articles in this issue: Biological Sciences – Agricultural Sciences: Mesoamerican origin of the common bean (Phaseolus vulgaris L.) is revealed by sequence data. Biological Sciences – Developmental Biology: Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled. Biological Sciences – Medical Sciences: Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling. Cell biology: Time-lapse two-color 3D imaging of live cells with doubled resolution using structured illumination. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Tue, 03 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-340 Articles in this issue: ORIGINAL ARTICLES: Cell biology: Aldo-Keto Reductase 1C3 Is Expressed in Differentiated Human Epidermis, Affects Keratinocyte Differentiation, and Is Upregulated in Atopic Dermatitis. Clinical research: Physical and Mental Impact of Psoriasis Severity as Measured by the Compact Short Form-12 Health Survey (SF-12) Quality of Life Tool. Evaluation of Reliability, Validity, and Responsiveness of the CDASI and the CAT-BM. Connective tissue: The Organotelluride Catalyst (PHTE)2NQ Prevents HOCl-Induced Systemic Sclerosis in Mouse. Genetics: Genome-Wide Meta-Analysis of Psoriatic Arthritis Identifies Susceptibility Locus at REL. Imumnology/infection: Pathogenic Anti-Desmoglein 3 mAbs Cloned from a Paraneoplastic Pemphigus Patient by Phage Display. Mon, 02 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m04 jurnal-347 Articles in this issue: REVIEWS: Regulation of cytoplasmic mRNA decay. The human microbiome: at the interface of health and disease. Endogenous viruses: insights into viral evolution and impact on host biology. PROGRESS: Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Mon, 02 Apr 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-252 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-254 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-256 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-258 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-260 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-261 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-264 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-265 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-271 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-273 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-275 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-277 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-279 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-281 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-283 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-295 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-318 Articles in this issue: RESEARCH: Effectiveness of physical activity promotion based in primary care: systematic review and meta-analysis of randomised controlled trials. Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis. Cardiovascular disease in kidney donors: matched cohort study. Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study. Patient safety in developing countries: retrospective estimation of scale and nature of harm to patients in hospital. Trends in socioeconomics inequalities in risk of sudden infant death syndrome, other causes of infant mortality, and stillbirth in Scotland: population based study. Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-320 Articles in this issue: Failure rates of stemmed metal-on-metal hip replacements: analysis of data from the National Joint of England and Wales. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Equity in maternal, newborn, and child health interventions in Countdown to 2015: Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-325 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-361 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-363 Sat, 31 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-322 Článek v tomto čísle: "Major taste loss in carnivorous mammals": Je známo, že většina savců vnímá pět základních chutí: sladké, hořké, kyselé, slané a umami. Receptory pro sladké, hořké a umami chutě jsou G proteiny-receptory (GPCRs). Savčí sladká chuť je primárně zprostředkována pomocí heteromer dvou úzce spojených chuťových receptorů typu 1 - Tas1r2/Tas1r3, zatímco hořká a umami chuť je zprostředkována receptory Tas2r rodiny A GPCRs. Jsou strukturálně nesourodé s receptory typu1. Přímé důkazy pro úzkou korelaci mezi chutí a ekologií krmení přicházejí z práce zaměřující se na divoké kočkovité šelmy. Kočkovité šelmy, obligátní masožravci, jsou behaviorálně citlivé na sladce chutnající sloučeniny. Bylo navrženo, že toto chování necitlivosti ke sladké chuti je způsobeno přítomností pseudogenu Tas1r2. Tas1r2 je také znám u kuřat, drápatky i upírů. Zkoumali celkem 12 druhů zvířat (pandy, lachtany, kytovce,...), která se živí výhradně masem, mělo pseudogeny Tas1r2, jak se předpokládalo. Dále byla potvrzena hypotéza, že kromě ztráty Tas1r1 a Tas1r3, což naznačuje absenci jak právě sladké, tak i umami chuti. Závěrem vyplývá, že ztráta chuti je mnohem rozšířenější, než se dříve myslelo a že tyto ztráty jsou v souladu se strategií krmení. Fri, 30 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-323 Článek v tomto čísle: Polní výzkum u včel: obavy ze snížení stavu včel kvůli dávkám pesticitů: Systémové insekticidy jsou včleněny zpracovanými rostlinami. Hmyz přijme insekticid zatímco se živí rostlinami. Insekticidy chrání úrodu, ale zároveň poškozují důležité opylovače jako jsou včely. Byly zaznamenány dvě hlášení z terénních studií. Čmeláci byli vystaveny jedné takové chemikálii, která vedla ke ztrátě královny. Tento příklad by mohl napomoci snížení počtu čmeláků. Další studie u včel uvádí, že insekticid narušil schopnost dělnice najít cestu zpět domů do úlu. Výzkumníci tvrdí, že tyto nálezy jsou důvodem k obavám, a proto by se měl zvyšovat tlak na zlepšení testování pesticidů a jejich regulaci. Fri, 30 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-317 Articles in this issue: INSIDE BLOOD: Gene therapy, an ongoing revolution. Homocysteine and thrombosis: guilt by association?. BLOOD WORK: A young patient with multiple myeloma. CLINICAL TRIALS AND OBSERVATIONS: Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs. Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients. HEMATOPOIESIS AND STEM CELLS: The combination of valproic acid and lithium delays hematopoietic stem/progenitor cell differentiation. TROMBOSIS AND HEMOSTASIS: Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs. Thu, 29 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-321 Articles in this issue: NEWS & VIEWS: Drug discovery: Cell lines battle cancer. Cancer: Clinical trials unite mice and humans. Palaeoclimate: Tahitian record suggests Antarctic collapse. Photonics: Terahertz collisions. Human evolution: Those feet in ancient times. ARTICLES: Ice-sheet collapse and sea-level rise at the Bølling warming 14,600 years ago. A new hominin foot from Ethiopia shows multiple Pliocene bipedal adaptations. Systematic identification of genomic markers of drug sensitivity in cancer cells. Thu, 29 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-324 Articles in this issue: ORIGINAL ARTICLES: Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis. Lifestyle Change and Mobility in Obese Adults with Type 2 Diabetes. CLINICAL THERAPEUTICS: Endoscopic Treatment of Primary Vesicoureteral Reflux. REVIEW ARTICLE: Mechanisms of Disease: Diabetic Retinopathy. Thu, 29 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-319 Articles in this issue: ORIGINAL CONTRIBUTIONS: Trends in cardiovascular health metrics and associations with all-cause and CVD mortality among US adults. Out-of-pocket medication costs and use of medications and health care services among children with asthma. MEDICAL NEWS & PERSPECTIVES: Studies examine fetal surgery trade-offs, drug interactions, and uterine rupture. Cancer experts recommend introducing palliative care at time of diagnosis. Wed, 28 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-362 Články v tomto čísle: PŘEHLEDOVÉ ČLÁNKY: Nádory štítné žlázy - molekulárně genetické příčiny a možnosti cílené léčby. Autofagie a její úloha v obranné a poškozující zánětové reakci. PŮVODNÍ PRÁCE: Faktory ovlivňující experimentování s kouřením: výsledky studie ELSPAC. SPECIÁLNÍ ODDĚLENÍ: Kurz koordinátorů HPH (Healt Promoting Hospitals, Nemocnic podporujících zdraví) a podzimní škola WHO v Praze. Mon, 26 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-310 Articles in this issue: NEWS: UK regulator asks cardiologists to report adverse effects of heart device. European research is launched into hypothermia stroke treatment. Trial is started to see whether gene therapy can improve lung function in cystic fibrosis. RESEARCH: Evaluation of a peer led parenting intervention for disruptive behavior problems in children: community based randomised controlled trial. ANALYSIS: Who is shaping the future of European health systems? Sat, 24 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-312 Articles in this issue: PERSPECTIVES: A historian's indictment of the US tobacco industry. The life, death, and mystery of Tutankhamen. ARTICLES: Dutasteride in localised prostate cancer management: the REDEEM randomised, double-blind, placebo-controlled trial. Increasing incidence of serious infectious diseases and inequalities in New Zealand: a national epidemiological study. Prevention of sexually transmitted infections in urban communities (Peru PREVEN): a multicomponent community-randomised controlled trial. CASE REPORT: Rash diagnosis of blood expectoration. Sat, 24 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-315 Articles in this issue: NEWS & ANALYSIS: Immunology: Gut Microbes Keep Rare Immune Cells in Line. PERSPECTIVES: Medicine: Old Drug, New Hope for Alzheimer's Disease. Geophysics: At the Bottom of the Oceanic Plate. Ecology: Keystones in a Tangled Bank. Neuroscience: The Imaginary Mind of a Mouse. Review: Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs. Fri, 23 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-309 Articles in this issue: INSIDE BLOOD: When monocyte life hangs by a thread. Good T cells for bad B cells. EPCR encryption induces cellular APC resistance. CLINICAL TRIALS AND OBSERVATIONS: B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells. A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes. Transplantation in patients with SCID: mismatched related stem cells or unrelated cord blood?. GENE THERAPY: B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells. Thu, 22 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-313 Articles in this issue: NEWS & VIEWS: Evolutionary biology: Life imperfectly imitates life. Molecular biology: How to duplicate a DNA package. Quantum plasmon resonances of individual metallic nanoparticles. Virology: Influenza's tale of tails. Neurodegeneration: Trouble in the cell's powerhouse. Biological physics: Swarming microtubules. Geochemistry: Bubbles from the deep. Microscopy: Plasmons go quantum. ARTICLES: Suppression of the antiviral response by an influenza histone mimic. Intrinsic coupling of lagging-strand synthesis to chromatin assembly. Thu, 22 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-316 Articles in this issue: Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia. Clonal Architecture of Secondary Acute Myeloid Leukemia. REVIEW ARTICLES: Medical Progress: Membranoproliferative Glomerulonephritis — A New Look at an Old Entity. Mechanisms of Disease: Monogenic Mitochondrial Disorders. Thu, 22 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-311 Articles in this issue: ORIGINAL CONTRIBUTIONS: Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants: A Randomized Controlled Trial. Utilization of Anesthesia Services During Outpatient Endoscopies and Colonoscopies and Associated Spending in 2003-2009. MEDICAL NEWS & PERSPECTIVES: Committee Calls for Framework to Assess the Safety of Nanotechnology Materials. Falls From Taking Multiple Medications May Be a Risk for Both Young and Old. Wed, 21 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-314 Článek v tomto čísle: Počátky hematopoetických kmenových buněk - Několik postojů uvádí, že dospělé hematopoetické buňky mají několik vývojových původů, ale ontogenetický vztah mezi "rodící se" hematopoetickou populací pod tímto schématem je uboze srozumitelný. Alternativní teorie uvádí, že prekurzory hematopoetických buněk vznikají z jednoho místa, které tak tvoří buněčný zdroj pro další krvetvorné populace. K modelaci ontogeneze krvetvorby k jejímu počátku byl navržen "počátek zachraňující systém", ve kterém je klíčovým faktorem krvetvorby gen Runx1, jež je reaktivován v určitých vývojových fázích. Pomocí doplňkových in vivo a ex vivo přístupů bylo zjišttěno, že "zralé" hematopoetické kmenové buňky pocházejí převážně ve vyvíjejícím se extraembryonálním mezodermu. Tue, 20 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-301 Articles in this issue: Implementation of mental health service recommendations in England and Wales and suicide rates, 1997–2006: a cross-sectional and before-and-after observational study. Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study. The effect of cord cleansing with chlorhexidine on neonatal mortality in rural Bangladesh: a community-based, cluster-randomised trial. Topical application of chlorhexidine to neonatal umbilical cords for prevention of omphalitis and neonatal mortality in a rural district of Pakistan: a community-based, cluster-randomised trial. CLINICAL PICTURE: Eye can see a nest of worms! Sat, 17 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-304 Articles in this issue: INFECTIOUS DISEASE: HIV Prevention and Cure Insights Come From Failure and Success. TOXICOLOGY: Heart-Stopping Revelation About How Chinese Mushroom Kills. PERSPECTIVES: Cell Biology: Membrane Bending Tug of War. Physiology: She Said No, Pass Me a Beer. REVIEW: The Fern Sporangium: A Unique Catapult. Fri, 16 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-308 Článek v tomto čísle: Alzheimer Mechanisms and Therapeutic Strategies: V léčbě Alzheimerovy choroby stále není zcela jasné, jak jí zastavit, popřípadě zcela potlačit její vznik. Genetické studie ukazují, že nemoc má několik příčin. Interdisciplinární přístupy kombinují biochemii, molekulární biologii a transgenní modelování a odhalují některé důležité mechanismy. Pokrok v oblasti chemie, radiologie začíná poskytovat užitečné biomarkery a nástup personalizované medicíny je na nejlepší cestě k transformaci farmaceutického vývoje a klinických studií. Fri, 16 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-299 Articles in this issue: BLOOD WORK: Erythroid leukemia evolving from multiple myeloma. CLINICAL TRIALS AND OBSERVATIONS: Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study. The Dynamic International Prognostic Scoring System for myelofibrosis predicts outcomes after hematopoietic cell transplantation. HEMATOPOIESIS AND STEM CELLS: S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. Asymmetric segregation and self-renewal of hematopoietic stem and progenitor cells with endocytic Ap2a2. TRANSPLANTATION: Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation. Thu, 15 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-302 Articles in this issue: NEWS & VIEWS: Organic chemistry: Catalysis in tight spaces. Developmental biology: A brainy background. Condensed-matter physics: A duo of graphene mimics. Biochemistry: Favouring the unfavoured. Electronics: Inside story of ferroelectric memories. Genetics: Broken giant linked to heart failure. Neuroscience: How brains learn to control machines. Gene expression: Transcription initiation unwrapped. ARTICLES: Ancient deuterostome origins of vertebrate brain signalling centres. Genome-wide structure and organization of eukaryotic pre-initiation complexes. Thu, 15 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-303 Článek v tomto čísle: Maximální rychlost vývoje savců: Jak rychle se savec vyvíjel od velikosti myši k velikosti slona? Dosažení tak velké proměny vyžaduje značnou biologickou reorganizaci. Použili jsme tuto hodnotu na vývoj tělesné hmotnosti u savců za posledních 70 milionů let, během nichž došlo v oceánech, na kontinentech a na ostrovech k velkým evolučním přechodům. Jejich výpočty ukazují, že to trvalo minimálně 1.6, 5.1 a 10 milionů generací pro pozemní savce. Zvýšení jejich hmotnosti bylo 100- a 1000- a 5000- krát. Hodnoty pro velryby se snížily na polovinu délky (tj. 1.1, 3 a 5 milionů generací). Thu, 15 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-305 Articles in this issue: Prostate-Cancer Mortality at 11 Years of Follow-up. Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale. Placebo-Controlled Trial of Oral Laquinimod for Multiple Sclerosis. Ingenol Mebutate Gel for Actinic Keratosis. Shattuck Lecture: A Successful and Sustainable Health System — How to Get There from Here. CLINICAL PRACTICE: Uncomplicated Urinary Tract Infection. Thu, 15 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-300 Articles in this issue: ORIGINAL CONTRIBUTIONS: Association of Hospital Spending Intensity With Mortality and Readmission Rates in Ontario Hospitals. Association Between Azithromycin Therapy and Duration of Bacterial Shedding Among Patients With Shiga Toxin–Producing Enteroaggregative Escherichia coli O104:H4. THE RATIONAL CLINICAL EXAMINATION: Does This Patient Have a Severe Upper Gastrointestinal Bleed? MEDICAL NEWS & PERSPECTIVES: International Debate Erupts Over Research on Potentially Dangerous Bird Flu Strains. Study Raises Concerns About “Heading” in Soccer, But Jury Is Still Out on Risks. Wed, 14 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-288 Articles in this issue: RESEARCH: Meta-analysis of individual patient data in randomised trials of self monitoring of blood glucose in people with non-insulin treated type 2 diabetes. Group art therapy as an adjunctive treatment for people with schizophrenia: multicentre pragmatic randomised trial. Primary screening for human papillomavirus compared with cytology screening for cervical cancer in European settings: cost effectiveness analysis based on a Dutch microsimulation model. Influence of definition based versus pragmatic birth registration on international comparisons of perinatal and infant mortality: population based retrospective study. Sat, 10 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-290 Articles in this issue: WORLD REPORT: Panel meeting prompts excitement for antiobesity drug. Costa Rica restructures health system to curb financial crisis. PERSPECTIVES: A history of eradication—successes, failures, and controversies. Knowing its place: mapping as medical investigation. ARTICLES: Association of a difference in systolic blood pressure between arms with vascular disease and mortality: a systematic review and meta-analysis. Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. CLINICAL PICTURE: Endocardial fibroelastosis of the heart. Sat, 10 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-293 Articles in this issue: NEWS & ANALYSIS: Surprising Twist in Debate Over Lab-Made H5N1. Report on Future of Fusion Research Says U.S. Should Hedge Its Bets. Last Hurrah: Final Tevatron Data Show Hints of Higgs Boson. NEWS FOCUS: Extraordinary Eyes. One Year After the Devastation, Tohoku Designs Its Renewal. Nuclear Ambivalence No More? PERSPECTIVES: Neuroscience: Youth Culture in the Adult Brain. Geochemistry: Moonstruck Magnetism. Social Science: Experimenting with Politics. Cell biology: Embryonic Clutch Control. Fri, 09 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-326 Článek v tomto čísle: "Large-Scale Gene-Centric Meta-Analysis across 39 studies indentifies type 2 diabetes loci": V březnovém čísel AHJG najdeme článek o genetickém základu diabetu druhého typu (T2D). Do jeho vzniku je zapojeno mnoho genů a vliv má i vnější prostředí. V minulosti bylo odhaleno více než 40 lokusů spojených s T2D. V minulosti byla zjištěna asociace mezi T2D a bodovými mutacemi u genů PPARG (MIM 601487) a KCNJ11 (MIM 600937). V rámci této studie byla provedena analýza 50 tisíc SNP u 2 tisíc genů (meta-analýza, GWAS) a následně určen jejich genetický podíl na rozvoj T2D. Fri, 09 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-287 Articles in this issue: INSIDE BLOOD: Cardiovascular string theory. Related or unrelated donor. REVIEW ARCTICLE: Targeting hedgehog in hematologic malignancy. CLINICAL TRIALS AND OBSERVATIONS: Thrombocythemia and polycythemia in patients younger than 20 years at diagnosis: clinical and biologic features, treatment, and long-term outcome. Rituximab decreases the risk of lymphoma in patients with HIV-associated multicentric Castleman disease. HEMATOPOIESIS AND STEM CELL: GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry. IMMUNOBIOLOGY: PIP2-dependent regulation of Munc13-4 endocytic recycling: impact on the cytolytic secretory pathway. CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells. HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8–like chemokine activity on monocytes through Rho/ROCK activation. MYELOID NEOPLASIA: Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene. Thu, 08 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-291 Articles in this issue: RESEARCH: Social science: Human reproductive assistance. Physical chemistry: Single molecules filmed dancing on a table top. Cell biology: The sensation of stretch. Geochemistry: A rusty carbon sink. Materials science: Continuity through dispersity. ARTICLES: Insights into hominid evolution from the gorilla genome sequence. Piezo proteins are pore-forming subunits of mechanically activated channels. Type VI secretion requires a dynamic contractile phage tail-like structure. Thu, 08 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-292 Articles in this issue: BIOLOGICAL SCIENCES - BIOCHEMISTRY: Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors. BIOLOGICAL SCIENCES - BIOPHYSICS AND COMPUTATIONAL BIOLOGY: Helical insertion of peptidoglycan produces chiral ordering of the bacterial cell wall. BIOLOGICAL SCIENCES - GENETICS: Alternative pathway of cell death in Drosophila mediated by NF-κB transcription factor Relish. BIOLOGICAL SCIENCES - IMMUNOLOGY: The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. ENGINEERING: Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Thu, 08 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-294 Articles in this issue: ORIGINAL ARTICLES: Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease. Enzyme-Replacement Therapy in Life-Threatening Hypophosphatasia. REVIEW ARTICLE: Current Concepts: Dysfunction of the Diaphragm. Thu, 08 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-289 Articles in this issue: ORIGINAL CONTRIBUTIONS: Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy: A Randomized Trial. Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production: A Randomized Controlled Trial. CLINICAL CROSSROADS: Use of Quality Indicators in Patient Care: A Senior Primary Care Physician Trying to Take Good Care of His Patients. MEDICAL NEWS & PERSPECTIVES: Effects of FDA Safety Warnings May Vary. Wed, 07 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-255 Articles in this issue: RESEARCH: Acute cannabis consumption and motor vehicle collision risk: systematic review of observational studies and meta-analysis. Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study. Health symptoms during midlife in relation to menopausal transition: British prospective cohort study. Impact of single centre status on estimates of intervention effects in trials with continuous outcomes: meta-epidemiological study. Sat, 03 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-263 Articles in this issue: Trends in access to health services and financial protection in China between 2003 and 2011: a cross-sectional study. Prevalence of chronic kidney disease in China: a cross-sectional survey. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. REVIEW: Early appraisal of China's huge and complex health-care reforms. CASE REPORT: Syncope: a rare manifestation of a common condition. Sat, 03 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-257 Articles in this issue: Single-Cell Exome Sequencing and Monoclonal Evolution of a JAK2-Negative Myeloproliferative Neoplasm. Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor. Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations. Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia. Neuropeptide Delivery to Synapses by Long-Range Vesicle Circulation and Sporadic Capture. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-259 Articles in this issue: Hematopoietic Stem Cell Subtypes Expand Differentially during Development and Display Distinct Lymphopoietic Programs. Functional Antagonism between Sall4 and Plzf Defines Germline Progenitors. Genetic Regulators of a Pluripotent Adult Stem Cell System in Planarians Identified by RNAi and Clonal Analysis. Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-262 Articles in this issue: REVIEWS: Defining Keratin Protein Function in Skin Epithelia: Epidermolysis Bullosa Simplex and Its Aftermath. Desmoglein as a Target in Skin Disease and Beyond. Shining a Light on Xeroderma Pigmentosum. Old and New: Recent Innovations in Vaccine Biology and Skin T Cells. Understanding the Evolution of Human Pigmentation: Recent Contributions from Population Genetics. Antimicrobial Peptides: Old Molecules with New Ideas. Genetics and Epigenetics of the Skin Meet Deep Sequence. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-267 Articles in this issue: NEWS & VIEWS: Self-fertilization sweeps up variation in the worm genome. Connecting complex disorders through biology. ANALYSIS: Differential confounding of rare and common variants in spatially structured populations. Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. ARTICLES: Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-268 Articles in this issue: REVIEWS: The insulin and insulin-like growth factor receptor family in neoplasia: an update. Epithelial stem cells, wound healing and cancer. The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention. The nuclear envelope environment and its cancer connections. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-269 Articles in this issue: REVIEWS: Understanding transgenerational epigenetic inheritance via the gametes in mammals. Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity. Human genetic susceptibility to infectious disease. Transcription as a source of genome instability. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-270 Articles in this issue: REVIEWS: Selection of regulatory T cells in the thymus. Accessory molecules for Toll-like receptors and their function. The role of interleukin-2 during homeostasis and activation of the immune system. Standardizing immunophenotyping for the Human Immunology Project. Living in the liver: hepatic infections. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-274 Článek v tomto čísle: Vědci objevili nové stopy zvířecí virové choroby / Kai Kupferschmidt: Virus Schmallenberg (podle německého města) se nejprve objevil v Německu a Nizozemsku koncem loňského roku, nyní už je rozšířen ve Francii, Belgii, Velké Británii, Itálii a Lucembursku. Vyskytuje se u hospodářských zvířat a způsobuje narození mrtvých mláďat nebo jejich deformace. Vědci se usilovně snaží zjistit, odkud virus pochází a jak se přenáší. Poprvé identifikovali nový virus v listopadu 2011 v krevních vzorcích odebraných z krav, které ukázaly mírné infekce v pozdním létě. Nyní, po prvních měsících infekce, více než 1400 zemědělských podniků v celé Evropě hlásí závažné příznaky u novorozených ovcí, koz a krav. Zdá se, že virus infikoval plody březích zvířat loni v létě, s katastrofálními následky pro potomstvo, které se projevují teprve nyní.Nejlepší odhadem pro šíření tohoto viru je tedy hmyz, ale nedají se vyloučit ani jiné způsoby přenosu (fekálně-orální přenos mezi zvířaty, aerosol či přímý kontakt). Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-276 Articles in this issue: CLINICAL REVIEWS IN ALLERGY AND IMMUNOLOGY: The long quest for neonatal screening for severe combined immunodeficiency. MECHANISMS OF ALLERGIC DISEASES: Laboratory technology for population-based screening for severe combined immunodeficiency in neonates: The winner is T-cell receptor excision circles. ASTHMA AND LOWER AIRWAY DISEASE: Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity. Relating small airways to asthma control by using impulse oscillometry in children. Asthma diagnosis and airway bronchodilator response in HIV-infected patients. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-278 Articles in this issue: CELLULAR IMMUNOLOGY AND IMMUNE REGULATION: Multiple Receptors Trigger Human NK Cell-Mediated Cytotoxicity against Porcine Chondrocytes. A Transgenic Model of Central Nervous System Autoimmunity Mediated by CD4+ and CD8+ T and B Cells. HLA Anchor Optimization of the Melan-A–HLA-A2 Epitope within a Long Peptide Is Required for Efficient Cross-Priming of Human Tumor-Reactive T Cells. Differential Regulation of Primary and Memory CD8 T Cell Immune Responses by Diacylglycerol Kinases. MOLECULAR AND STRUCTURAL IMMUNOLOGY: Structural and Functional Characterization of a Novel Nonglycosidic Type I NKT Agonist with Immunomodulatory Properties. IMMUNOGENETICS: Skewed Primary Igκ Repertoire and V–J Joining in C57BL/6 Mice: Implications for Recombination Accessibility and Receptor Editing. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-280 Articles in this issue: Intermittent preventive therapy for malaria with monthly artemether–lumefantrine for the post-discharge management of severe anaemia in children aged 4–59 months in southern Malawi: a multicentre, randomised, placebo-controlled trial. Diagnostic accuracy of a low-cost, urine antigen, point-of-care screening assay for HIV-associated pulmonary tuberculosis before antiretroviral therapy: a descriptive study. Global burden of human food-borne trematodiasis: a systematic review and meta-analysis. REVIEW: Antiviral resistance during the 2009 influenza A H1N1 pandemic: public health, laboratory, and clinical perspectives. CLINICAL PICTURE: Disseminated cutaneous Mycobacterium chelonae. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-284 Článek v tomto čísle: The role of vitamin D in the immunopathogenesis of allergic skin diseases - Vitamín D hraje klíčovou roli v imunitním systému člověka. Zapojuje se při stimulaci Toll-like receptorů, zvyšuje produkci zánětlivých cytokinů a má tak mimo jiné vliv na rozvoj alergií včetně astma a potravinových alergií. Tento článek se zabývá vlivem vitamínu D na rozvoj atopické dermatitidy a ostatních onemocnění kůže. Je těžké posoudit, jestli nízká hladina vitamínu D vede ke vzniku alergických onemocnění kůže, nebo naopak onemocnění kůže zhoršuje absorpci vitamínu D. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-296 Articles in this issue: STEM CELL PROCUREMENT: Proposed definition of ‘poor mobilizer’ in lymphoma and multiple myeloma: an analytic hierarchy process by ad hoc working group Gruppo ItalianoTrapianto di Midollo Osseo. PEDIATRIC TRANSPLANT: Allogeneic hematopoietic SCT for alpha-mannosidosis: an analysis of 17 patients. IgG antibodies to ATG early after pediatric hematopoietic SCT increase the risk of acute GVHD. The outcome of allo-HSCT for 92 patients with myelofibrosis in the Nordic countries. Clinical significance of hemophagocytosis in BM clot sections during the peri-engraftment period following allogeneic hematopoietic SCT. M-CSF attenuates severity of chronic GVHD after unrelated BMT. Fri, 02 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-253 Articles in this issue: INSIDE BLOOD: Unveiling the complexity of CK+ AML. VWF sequence variants: innocent until proven guilty. BLOOD WORK: Aleukemic variant of mast cell leukemia. REVIEW ARTICLE: Selection of optimal alternative graft source: mismatched unrelated donor, umbilical cord blood, or haploidentical transplant. IMMUNOBIOLOGY: Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection. Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates. Thu, 01 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-266 Articles in this issue: NEWS & VIEWS: Palaeobotany: In the shade of the oldest forest. Microfluidics: Analog-to-digital drug screening. Catalysis: Disguise gets a reaction. Translational medicine: Primed for resistance. ARTICLES: Gain control by layer six in cortical circuits of vision. Structural basis for iron piracy by pathogenic Neisseria. Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Thu, 01 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-272 Článek v tomto čísle: Regulace axiální rotace kuřecího embrya v raných fázích vývoje pomocí nervového růstového faktoru. Nervový růstový faktor (NGF) byl objeven díky jeho neuronální reakci na smyslové neurony ve vyvíjejícím se embryu kuřete. Dále bylo zjištěno, že NGF ovlivňují a regulují funkci mnoha neuronů i dalších buněk u dospělých organismů. Už jsou však méně známé možné dopady NGF během časných embryonálních stádií. Avšak následně bylo zjištěno, že mRNA kódující NGF a jeho receptory TrkA a p75NTR se u ptáků exprimují ve velmi časných stádiích vývoje, ještě před utvářením nervového systému. Otázkou tedy zůstává, jakou funkci by NGF mohl mít v raném vývoji kuřecího embrya, před vývojem senzorických neuronů. Možné role NFG v počátečních fázích vývoje zkoumali tak, že některým kuřecím embryím píchli injekci s protilátkou proti NGF (MABαD11), která se váže na zralá NGF s vysokou afinitou. Léčbě proti NGF vedla k převrácení embrya ve směru axiální rotace. Takto změněná rotace (s injekcí proti NGF) byla spojena se zvýšením buněčné smrti u somitů. Thu, 01 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m03 jurnal-282 Articles in this issue: A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis - "This trial showed clinically significant responses in spleen size and quality of life among patients with myelofibrosis receiving ruxolitinib, a JAK1 and JAK2 inhibitor. The agent has some myelotoxicity, but this study showed a survival advantage with ruxolitinib". A Randomized Trial of Nicotine-Replacement Therapy Patches in Pregnancy - "In this placebo-controlled trial, the addition of a nicotine patch to behavioral support for smoking cessation did not significantly increase rates of prolonged abstinence lasting until delivery, nor did it affect rates of adverse pregnancy and birth outcomes. Compliance rates were low". HEALTH LAW, ETHICS, AND HUMAN RIGHTS: Regulation of Medical Devices in the United States and European Union - "As compared with Europe, the United States generally requires more rigorous clinical testing of high-risk devices, which delays patients' access to new devices but may provide better assurance of device safety". Thu, 01 Mar 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-170 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-172 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-174 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-176 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-179 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-184 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-186 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-188 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-190 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-192 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-194 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-197 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-199 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-201 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-203 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-220 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-248 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-250 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-285 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-364 Wed, 29 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-365 Články v tomto čísle: PŘEHLEDY: Charakteristika akutních otrav v seniorském věku. Gluténová enteropatie. Z RŮZNÝCH OBORŮ: Primární prevence v ordinaci všeobecného praktického lékaře. Použití epidemiologických dat při odhadu rizika karcinogenity a princip předběžné bezpečnosti. Primární péče v České republice v letech 2005-2010. Stresové situace lékaře jako pacienta: komunikace, vyšetření, zkušenost, etika. Elektronická dokumentace pro ošetřovatelskou diagnostiku v domácí péči. Podprahové vnímání, medicína a návykové nemoci. Hodnocení potřeb terminálně nemocných v domácí péči: pilotní studie. HISTORIE/FEJETON: Pawlik Karel - světoznámý gynekolog a porodník. Mon, 27 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-239 Articles in this issue: RESEARCH: Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trial. Understanding recent trends in incidence of invasive breast cancer in Norway: age-period-cohord analysis based on registry data on mammography screening and hormone treatment use. ANALYSIS: Hospital service reconfiguration: the battle for hearts and minds. Sat, 25 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-241 Articles in this issue: Embryonic stem cell trials for macular degeneration: a preliminary report. Lithium toxicity profile: a systematic review and meta-analysis. Effectiveness of community case management of severe pneumonia with oral amoxicillin in children aged 2–59 months in Matiari district, rural Pakistan: a cluster-randomised controlled trial. REVIEW: Medical complications associated with earthquakes. Child maltreatment: variation in trends and policies in six developed countries. PERSPECTIVES: Spectacular anatomy: plastination and salutary dread. Sat, 25 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-244 Articles in this issue: NEWS & ANALYSIS: WHO Group: H5N1 Papers Should Be Published in Full. Scientists Decry Cuts That Would Doom ExoMars Missions. Bigger Contribution to ITER Erodes Domestic Fusion Program. NEWS FOCUS: India's Scholar-Prime Minister Aims for Inclusive Development. Crowd-Sourcing Drug Discovery. PERSPECTIVES: Frictional Dissipation—Blame It on the Rain. Solving Amorphous Structures—Two Pairs Beat One. RESEARCH ARTICLE: Evolution of Shape by Multiple Regulatory Changes to a Growth Gene. Fri, 24 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-245 Articles in this issue: Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths - "On the basis of long-term follow-up data from the National Polyp Study, the authors estimate that mortality from colorectal cancer was about 50% lower among patients who had adenomatous polyps removed than in the general population". Colonoscopy versus Fecal Immunochemical Testing in Colorectal-Cancer Screening - "This trial comparing colorectal-cancer mortality among patients screened with colonoscopy or fecal immunochemical testing (FIT) will be completed in 2021. As compared with FIT, colonoscopy detected a similar number of cancers but more adenomas on baseline screening". Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib. Brief Report: Three Patients with Full Facial Transplantation. Fri, 24 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-249 Articles in this issue: Interleukin-4 Production by Follicular Helper T Cells Requires the Conserved Il4 Enhancer Hypersensitivity Site V. The 3′ Enhancer CNS2 Is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells. Rarity of Human T Helper 17 Cells Is due to Retinoic Acid Orphan Receptor-Dependent Mechanisms that Limit Their Expansion. Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation. The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity. Intravital Imaging of Thymopoiesis Reveals Dynamic Lympho-Epithelial Interactions. Fri, 24 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-238 Articles in this issue: INSIDE BLOOD: Amyloidomics comes of age. “Radical” model of thrombosis. PERSPECTIVES: Emerging roles for multipotent, bone marrow–derived stromal cells in host defense. REVIEW ARTICLE: Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. CLINICAL TRIALS AND OBSERVATIONS: Responses to second-line tyrosine kinase inhibitors are durable: an intention-to-treat analysis in chronic myeloid leukemia patients. Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma. HEMATOPOIESIS AND STEM CELLS: Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain. Thu, 23 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-242 Articles in this issue: NEWS & VIEWS: Cell biology: Collagen secretion explained. Fluid mechanics: Mist opportunities. Structural biology: Muscarinic receptors become crystal clear. Climate change: Shrinking glaciers under scrutiny. Astrophysics: First results from Planck observatory. Cancer genetics: Evolution after tumour spread. ARTICLES: Experimental demonstration of topological error correction. Ubiquitin-dependent regulation of COPII coat size and function. Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. Thu, 23 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-243 Articles in this issue: SOCIAL SCIENCES - ANTHROPOLOGY: Heterogeneity of hunting ability and nutritional status among domestic dogs in lowland Nicaragua. BIOLOGICAL SCIENCES - CELL BIOLOGY: Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis. BIOLOGICAL SCIENCES - NEUROSCIENCE: Phoneme and word recognition in the auditory ventral stream. Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses. CHEMISTRY: Unusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpecker. Thu, 23 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-240 Articles in this issue: MEDICAL NEWS & PERSPECTIVES: Smuggled Wildlife Products Seized at US Airports Harbor Zoonotic Viruses. Patient-Centered Medical Homes Offer a Model for Better, Cheaper Health Care. FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION: Notes From the Field: Escherichia coli O157:H7 Gastroenteritis Associated With a State Fair—North Carolina, 2011. Wed, 22 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-230 Articles in this issue: RESEARCH: Efficacy and safety of enoxaparin versus unfractionated heparin during percutaneous coronary intervention: systematic review and meta-analysis. Physical activity for cancer survivors: meta-analysis of randomised controlled trials. Systematic review of peer support for breastfeeding continuation: metaregression analysis of the effect of setting, intensity, and timing. Influence of medical journal press releases on the quality of associated newspaper coverage: retrospective cohort study. Sat, 18 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-233 Articles in this issue: Immunogenicity and tolerability of a multicomponent meningococcal serogroup B (4CMenB) vaccine in healthy adolescents in Chile: a phase 2b/3 randomised, observer-blind, placebo-controlled study. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials. REVIEW: Clinical xenotransplantation: the next medical revolution? Sat, 18 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-231 Article in this issue: Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer. Mechanism of Transcription Initiation at an Activator-Dependent Promoter Defined by Single-Molecule Observation. Spt4 Is Selectively Required for Transcription of Extended Trinucleotide Repeats. A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing. Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity. Regulation of Circadian Behavioral Output via a MicroRNA-JAK/STAT Circuit. THEORY: Identification of F-actin as the Dynamic Hub in a Microbial-Induced GTPase Polarity Circuit. Fri, 17 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-236 Articles in this issue: PERSPECTIVES: A Cold Editor Makes the Adaptation - "Adaptation to cold temperature is mediated by RNA editing of a potassium channel in octopus neurons". Gene Losses in the Human Genome - "A comprehensive survey of the human genome reveals variations that disrupt protein-coding genes". Adding Aliphatic C–H Bond Oxidations to Synthesis - "Oxidations of aliphatic C–H bonds, known since the 1800s, have only recently been considered for use in organic synthesis". Fri, 17 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-229 Articles in this issue: INSIDE BLOOD: The right dose for the right patient. Giving TRALI the one-two punch. REVIEW ARTICLES: Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs. Model systems of genetically modified platelets. CLINICAL TRIALS AND OBSERVATIONS: Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases. Transfusion-related acute lung injury: incidence and risk factors. HEMATOPOIESIS AND STEM CELLS: The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. IMMUNOBIOLOGY: Morbidity and mortality in common variable immune deficiency over 4 decades. Thu, 16 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-234 Articles in this issue: NEWS & VIEWS: Biodiversity: Species choked and blended. Microbiology: A sweet way of sensing danger. Structural biology: Ion channel in the spotlight. Analytical chemistry: Ultrasensitive radiocarbon detection. Earth science: Intraplate volcanism. Astrophysics: Echoes from an old outburst. ARTICLES: Eutrophication causes speciation reversal in whitefish adaptive radiations. Prions are a common mechanism for phenotypic inheritance in wild yeasts. Crystal structure of the channelrhodopsin light-gated cation channel. Thu, 16 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-237 Articles in this issue: Intramuscular versus Intravenous Therapy for Prehospital Status Epilepticus - "In this trial, subjects in status epilepticus were given either intramuscular midazolam or intravenous lorazepam by paramedics before arrival in the ER. Seizures were controlled in more subjects with midazolam, and midazolam was at least as safe and effective as lorazepam". Truncations of Titin Causing Dilated Cardiomyopathy - "Titin, an important protein in the sarcomere, is the largest human protein. This study identified mutations in the titin gene that result in a truncated protein as important causes of dilated cardiomyopathy". REVIEW ARTICLE: Current Concepts: The Autosomal Recessive Cerebellar Ataxias - "Autosomal recessive cerebellar ataxia must be considered in any child or young adult with a progressive disorder of gait or balance or with hypotonia or excessive clumsiness. This review presents a practical approach to these neurodegenerative diseases". Thu, 16 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-232 This week in JAMA: ORIGINAL CONTRIBUTIONS: Vitamin D Therapy and Cardiac Structure and Function in Patients With Chronic Kidney Disease: The PRIMO Randomized Controlled Trial. Amoxicillin for Acute Rhinosinusitis: A Randomized Controlled Trial. Moderate to Vigorous Physical Activity and Sedentary Time and Cardiometabolic Risk Factors in Children and Adolescents. CLINICAL REVIEW: Main Air Pollutants and Myocardial Infarction: A Systematic Review and Meta-analysis. MEDICAL NEWS & PERSPECTIVES: Federal Agencies Poised to Help Improve Health Literacy in the United States. Osteoporosis Screening May Be Needed Less Often Than Previously Believed. Wed, 15 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-235 Articles in this issue: Critical role for protein kinase A in the acquisition of gregarious behavior in the desert locust. BIOLOGICAL SCIENCES - CELL BIOLOGY: Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. BIOLOGICAL SCIENCES - EVOLUTION: Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales. Tight coevolution of proliferating cell nuclear antigen (PCNA)-partner interaction networks in fungi leads to interspecies network incompatibility. BIOLOGICAL SCIENCES - IMMUNOLOGY: Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm. Tue, 14 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-222 Articles in this issue: RESEARCH: Effectiveness of agricultural interventions that aim to improve nutritional status of children: systematic review. Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial. Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case-control study. Influence of experience on performance of individual surgeons in thyroid surgery: prospective cross sectional multicentre study. ANALYSIS: Pragmatic randomised trials using routine electronic health records: putting them to the test. Sat, 11 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-224 Articles in this issue: Effect of age on decisions about the numbers of embryos to transfer in assisted conception: a prospective study. Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial. Clinical features of paediatric pulmonary hypertension: a registry study. Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis. CLINICAL PICTURE: Profound pectus excavatum in Marfan's syndrome. Sat, 11 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-227 Articles in this issue: NEWS FOCUS: Indoor Ecosystems - "The microbial ecology of buildings gets a boost from a foundation and researchers trying to better understand the invisible communities in our homes, hospitals, and workspaces". PERSPECTIVES: NEUROSCIENCE: Ode to the Mushroom Bodies - "Neurons that stabilize memory storage are located outside of a region in the insect brain long thought to handle this task". MATHEMATICS: Critical Truths About Power Laws - "Most reported power laws lack statistical support and mechanistic backing". IMMUNOLOGY: Remembering to Be Tolerant - "Self-tolerant T cells can be transiently reactivated". CHEMISTRY: Probing Frozen Molecular Embraces - "The conformation of the complex formed by a catalyst and its substrate was determined with a method that combined mass spectrometry and infrared spectroscopy". Fri, 10 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-219 Articles in this issue: INSIDE BLOOD: A new target for myeloma therapy. Tolerant heaven or mHEL trouble. High VWF, low ADAMTS13 puts women at risk. BLOOD WORK: Acute nonlymphocytic leukemia presenting with pancytopenia. REVIEW ARTICLE: EGFL7: a unique angiogenic signaling factor in vascular development and disease. CLINICAL TRIALS AND OBSERVATIONS: The principal results of the International Immune Tolerance Study: a randomized dose comparison. Thigh-length versus below-knee compression elastic stockings for prevention of the postthrombotic syndrome in patients with proximal-venous thrombosis: a randomized trial. Treatment, risk factors, and outcome of adults with relapsed AML after reduced intensity conditioning for allogeneic stem cell transplantation. HEMATOPOIESIS AND STEM CELLS: The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation. Thu, 09 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-225 Articles in this issue: Thermodynamics: The fridge gate. Genetics: How intelligence changes with age. Infectious disease: Genomics decodes drug action. Cell biology: Destruction deconstructed. Quantum optics: Controlling the light. ARTICLES: Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Complete subunit architecture of the proteasome regulatory particle. Thu, 09 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-226 Articles in this issue: BIOLOGICAL SCIENCES: Surprising complexity of the Asf1 histone chaperone-Rad53 kinase interaction. Significance analysis of xMap cytokine bead arrays. Active maintenance of nuclear actin by importin 9 supports transcription. Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan. BIOLOGICAL SCIENCES - CELL BIOLOGY: TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. BIOLOGICAL SCIENCES - GENETICS: Identification of innate immunity elicitors using molecular signatures of natural selection. Thu, 09 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-228 Articles in this issue: PERSPECTIVE: The Emerging Threat of Untreatable Gonococcal Infection. Preparing for Precision Medicine. ORIGINAL ARTICLES: Antenatal Thyroid Screening and Childhood Cognitive Function. Memory Enhancement and Deep-Brain Stimulation of the Entorhinal Area. Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer. REVIEW ARTICLE: Mechanisms of Disease: IgG4-Related Disease. Thu, 09 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-221 Articles in this issue: Single center retrospective analysis of BU-based conditioning regimens in allogeneic transplantation. Effect of genetic polymorphisms in genes encoding GST isoenzymes on BU pharmacokinetics in adult patients undergoing hematopoietic SCT. Similar outcomes using myeloablative vs reduced-intensity allogeneic transplant preparative regimens for AML or MDS. Allogeneic cellular gene therapy in hemoglobinopathies—evaluation of hematopoietic SCT in sickle cell anemia. Clinical features and outcome of 2009-influenza A (H1N1) after allogeneic hematopoietic SCT. Fertility after allogeneic haematopoietic stem cell transplantation in childhood and adolescence. Wed, 08 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-223 This week in JAMA: ORIGINAL CONTRIBUTIONS: Immunogenicity and Tolerability of Recombinant Serogroup B Meningococcal Vaccine Administered With or Without Routine Infant Vaccinations According to Different Immunization Schedules: A Randomized Controlled Trial. Cefpodoxime vs Ciprofloxacin for Short-Course Treatment of Acute Uncomplicated Cystitis: A Randomized Trial. Association Between Age at Diagnosis and Disease-Specific Mortality Among Postmenopausal Women With Hormone Receptor–Positive Breast Cancer. MEDICAL NEWS & PERSPECTIVES: NIH Program Helps Developers Navigate Path to New Drugs for Neglected Diseases. Heart Disease and Stroke Deaths Fall, But Some Fear a Reverse in the Trend. Wed, 08 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-195 This week in Lancet: WORLD REPORT: Regulation failing to keep up with India's trials boom. NICE epilepsy guidance “may be detrimental to patient care”. ARTICLES: Global malaria mortality between 1980 and 2010: a systematic analysis. Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised trials. Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review. Sat, 04 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-204 Articles in this issue: RESEARCH: Determinants of the decline in mortality from acute myocardial infarction in England between 2002 and 2010: linked national database study. The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review amd meta-analysis. ANALYSIS: Shared decision making: really patients at the centre of healthcare. OBSERVATIONS: Why legislation is necessary for my health reforms. Sat, 04 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-173 Articles in this issue: Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases. Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier. Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome. Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory. Modular Genetic Control of Sexually Dimorphic Behaviors. Fri, 03 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-175 Articles in this issue: Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs. BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells. A Mammary Stem Cell Population Identified and Characterized in Late Embryogenesis Reveals Similarities to Human Breast Cancer. Infection-Responsive Expansion of the Hematopoietic Stem and Progenitor Cell Compartment in Zebrafish Is Dependent upon Inducible Nitric Oxide. Fri, 03 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-177 Articles in this issue: ORIGINAL ARTICLES: CELL BIOLOGY: A Humanized Stromal Bed Is Required for Engraftment of Isolated Human Primary Squamous Cell Carcinoma Cells in Immunocompromised Mice. CLINICAL RESEARCH: Psoriasis and Risk of Type 2 Diabetes among Women and Men in the United States: A Population-Based Cohort Study. IMMUNOLOGY/INFECTION: Substance P (SP) Induces Expression of Functional Corticotropin-Releasing Hormone Receptor-1 (CRHR-1) in Human Mast Cells. KERATINOCYTES/EPIDERMIS: TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function. TUMOR BIOLOGY: Identification and Characterization of Tumor-Initiating Cells in Human Primary Cutaneous Squamous Cell Carcinoma. Fri, 03 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-178 Articles in this issue: NEWS & VIEWS: Arabidopsis thaliana as a model for the genetics of local adaptation. The genome of a blood fluke associated with human cancer. The persistence of a silent memory. ARTICLES: Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development. Fri, 03 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-181 Articles in this issue: REVIEWS: Targeting MET in cancer: rationale and progress - "Signalling through the receptor tyrosine kinase MET and its ligand hepatocyte growth factor/scatter factor (HGF/SF) has been associated with various types of cancer, which has led to numerous efforts to try and target these proteins. This Review discusses HGF/SF–MET signalling in cancer and current progress with targeting this pathway." Balancing repair and tolerance of DNA damage caused by alkylating agents - "Alkylating agents can both induce tumorigenesis and be used to treat cancer patients. However, responses to alkylating chemotherapeutic drugs are variable. This Review discusses the molecular responses to alkylating agents and the causes for such variation." PERSPECTIVES: Cancer stem cells: an evolving concept - "There is increasing debate about what is meant by the term 'cancer stem cell' (CSC) and the degree to which the concept of CSCs can provide insights into cancer biology and therapy. This Timeline article traces the historical milestones in normal and cancer stem cell biology as a backdrop to a discussion of how these fields have informed each other." Fri, 03 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-200 Articles in this issue: NEWS & ANALYSIS: Cell Biology: Donation Spurs a Cell Observatory—And Bigger Plans. Astronomy: Celebrated Exoplanet Vanishes in a Cloud of Dust—Or Maybe Not. NEWS FOCUS: Ecology: Rebuilding Wetlands by Managing the Muddy Mississippi. Oil Resources: Technology Is Turning U.S. Oil Around But Not the World's. Fri, 03 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-171 Articles in this issue: ORIGINAL ARTICLES: Prevention and treatment of DNA vaccine encoding cockroach allergen Bla g 1 in a mouse model of allergic airway inflammation. T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy. Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model. A multi-allergen standard for the calibration of immunoassays: CREATE principles applied to eight purified allergens. EPIDEMIOLOGY AND GENETICS: The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers. AIRWAY DISEASES: Daily exhaled nitric oxide measurements and asthma exacerbations in children. Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-182 Articles in this issue: REVIEWS: Crop genomics: advances and applications - "The increased availability of reference genomes and the ability to obtain resequencing data in larger quantities are changing the capabilities of crop comparative genomics. Insights into the genetic basis of domestication and agriculturally important traits are emerging, and improved genomic tools have implications for crop breeders and evolutionary biologists." Epigenetics and the environment: emerging patterns and implications - "There is considerable interest in exploring whether environmental factors, including chemicals and dietary components, can alter epigenomes. Environmentally induced changes in epigenetic marks are important in the development of several species, such as plants and insects; whether they influence human disease will be an area for future research." Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription. Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-183 Articles in this issue: REVIEWS: Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways - "Programmed cell death of infected host cells builds up the first line of defence against viruses. Here, Mocarski and colleagues describe the tight regulation of caspase 8-dependent apoptosis and programmed necrosis and discuss how viral inhibitors of cell death may have contributed to the evolution of programmed necrosis to promote host survival." Transcriptional programming of the dendritic cell network - "The dendritic cell (DC) network consists of several DC subsets with distinct functions. Here, Gabrielle Belz and Stephen Nutt focus on transcription factors that regulate DC lineage specification in response to developmental and environmental cues." Immunomodulatory functions of type I interferons - "Type I interferons (IFNs) have become synonymous with antiviral immunity. But, as discussed in this Review, type I IFNs also have roles in bacterial infections, in intestinal homeostasis and in inflammatory and autoimmune diseases." Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-185 Articles in this issue: REVIEWS AND FEATURE ARTICLES: Fungi and allergic lower respiratory tract diseases. CONTINUING MEDICAL EDUCATION EXAMINATION: Mendelian traits causing susceptibility to mucocutaneous fungal infections in human subjects. ASTMA AND LOWER AIRWAY DISEASE: Airway remodeling and inflammation in competitive swimmers training in indoor chlorinated swimming pools. The effect of single and multiple infections on atopy and wheezing in children. Interaction between filaggrin null mutations and tobacco smoking in relation to asthma. Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-187 Articles in this issue: CELLULAR IMMUNOLOGY AND IMMUNE REGULATION: Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells. Temporal Predisposition to αβ and γδ T Cell Fates in the Thymus. Th2 Skewing by Activation of Nrf2 in CD4+ T Cells. Human NK Cells Induce Neutrophil Apoptosis via an NKp46- and Fas-Dependent Mechanism. Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness. MOLECULAR AND STRUCTURAL IMMUNOLOGY: Conventional Dendritic Cells Require IRAP-Rab14 Endosomes for Efficient Cross-Presentation. IMMUNOGENETICS: A Proposed Algorithm Predictive for Cytotoxic T Cell Alloreactivity. Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-189 Articles in this issue: Once daily dolutegravir (S/GSK1349572) in combination therapy in antiretroviral-naive adults with HIV: planned interim 48 week results from SPRING-1, a dose-ranging, randomised, phase 2b trial. Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort study. Immunogenicity of supplemental doses of poliovirus vaccine for children aged 6–9 months in Moradabad, India: a community-based, randomised controlled trial. Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-191 Articles in this issue: INSIDE BLOOD: Cocktail of eternity: HDAC meets miR. Polycomb segment myeloid malignancies. HIT: treatment easier, prevention harder. BLOOD WORK: Yeast-like intraleukocytic inclusions in a peripheral smear. REVIEW ARTICLE: Hematopoietic stem cell engineering at a crossroads. CLINICAL TRIALS AND OBSERVATIONS: High-dose melphalan and peripheral blood stem cell transplantation for light-chain amyloidosis with cardiac involvement. Durable donor engraftment after radioimmunotherapy using α-emitter astatine-211–labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantation. GENE THERAPY: A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice. Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-196 Articles in this issue: NEWS & VIEWS: Volcanology: Greek inflation circa 1600 BC. Surface chemistry: Crystal cuts on the nanoscale. Plant biology: Equal-parenting policy. Neuroscience: Reward alters specific connections. ARTICLES: Conditional modulation of spike-timing-dependent plasticity for olfactory learning - "In the locust olfactory system, spike-timing-dependent plasticity acts as a synaptic ‘tag’ that labels only the synapses active in response to specific odorants, thus priming them for subsequent modulation of the plasticity rule." DNA breaks and chromosome pulverization from errors in mitosis - "Chromosomes within micronuclei are shown to be damaged during S phase and become highly fragmented, and the damaged pieces can be reincorporated into the genome." Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-198 This week in PNAS: BIOLOGICAL SCIENCES: Biochemistry: Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin. Biophysics and Computational Biology: Full-length myosin Va exhibits altered gating during processive movement on actin. MEDICAL SCIENCES: Glycogen synthase kinase 3β transfers cytoprotective signaling through connexin 43 onto mitochondrial ATP-sensitive K+ channels. Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. MICROBIOLOGY: Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses. Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-202 Articles in this issue: ORIGINAL ARTICLES: Ulipristal Acetate versus Leuprolide Acetate for Uterine Fibroids - "In this trial comparing oral ulipristal acetate (5 mg or 10 mg daily) with once-monthly leuprolide acetate in women with symptomatic uterine fibroids before planned surgery, both doses of ulipristal acetate were noninferior to leuprolide acetate in controlling uterine bleeding." CLINICAL PRACTICE: Delayed Puberty - "Puberty is considered delayed when it has not yet occurred at an age that is 2 to 2.5 SD later than average (traditionally, 14 years in boys and 13 years in girls). Constitutional delay of growth and puberty (CDGP) is the most common cause. Management of CDGP is discussed." Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-251 Článek v tomto čísle: Porcine uterus contains a population of mesenchymal stem cells (Katarzyna Miernik and Janusz Karasinski): Cílem této studie bylo charakterizovat buňky prasečí dělohy. Děloha má pozoruhodnou schopnost cyklické přeměny během života samice. Různé výzkumy dokázaly, že dospělé progenitorové kmenové buňky mohou hrát významnou roli v udržování homeostáze endometria. Vědci kmenové buňky kultivovali v in vitro podmínkách, kde potvrdili diferenciaci těchto buněk do adipogenní a osteogenní linie. Pro charakterizaci mezenchymálních kmenových buněk použili povrchové markery (CD 29, CD 44, CD 144, CD 105 a CD 140b). Jako negativní kontrolu použili hemopoetické markery kmenových buněk (CD 34 a CD 45) Závěr studie dokazuje, že děloha prasat obsahuje malou populaci nediferencovaných kmenových buněk s vlastnostmi podobnými lidským a myším kmenovým mezenchymálním buňkám. Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-286 Články v tomto čísle: PŘEHLEDOVÉ ČLÁNKY: Morfologie a etiopatogeneze aneuryzmatu břišní aorty. Mužský hypogonadismus a civilizační onemocnění. PUVODNÍ PRÁCE: Prevalence trombofilních mutací FV Leiden, protrombinu G20210A a PAI-1 4G/5G a jejich vzájemných kombinací v souboru 1450 zdravých osob středního věku v regionu Praha a střední Čechy. Problematika činností etických komisí. SPECIÁLNÍ SDĚLENÍ. ABSTRAKTA. SJEZDY. Thu, 02 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m02 jurnal-193 This week in JAMA: ORIGINAL CONTRIBUTIONS: Variability in Reexcision Following Breast Conservation Surgery. Association of Emergency Department Length of Stay With Safety-Net Status. Prevalence of Obesity and Trends in Body Mass Index Among US Children and Adolescents, 1999-2010. CLINICAL CROSSROADS: Weight Loss Strategies for Adolescents: A 14-Year-Old Struggling to Lose Weight. MEDICAL NEWS & PERSPECTIVES: Patient-Centered Care Model Demands Better Physician-Patient Communication. Programs to Reduce Childhood Obesity Seem to Work, Say Cochrane Reviewers. Wed, 01 Feb 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-99 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-103 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-104 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-108 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-144 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-157 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-159 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-163 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-210 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-211 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-213 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-297 Tue, 31 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-106 Mon, 30 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-109 Mon, 30 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-138 This week in Lancet: WORLD REPORT: CDC planning trial for mysterious nodding syndrome. BRCA patent dispute may head to US Supreme Court. Anticoagulant loses its lustre. Greece's financial crisis dries up drug supply. PERSPECTIVES: Beats and the brain. Joseph Rotblat's conscientious life in science and politics. ARTICLES: Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data. Neonatal screening for lysosomal storage disorders: feasibility and incidence from a nationwide study in Austria. Sat, 28 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-205 Articles in this issue: RESEARCH: Vitamin A supplementation in preschool children and risk of hearing loss as adolescents and young adults in rural Nepal: randomised trial cohort follow-up study. Effectivenes of vaccine against pandemic influenza A/H1N1 among people with underlying chronic diseases: cohort study, Denmark, 2009-10. Indentifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm. ANALYSIS: Navigating the shoals on the choice of blood pressure lowering drugs be simplifield?. Sat, 28 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-140 Articles in this issue: Biological Sciences - Biochemistry: The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family. Biological Sciences - Biophysics and Computational Biology: Aggregation of α-synuclein is kinetically controlled by intramolecular diffusion. Biological Sciences - Cell Biology: Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance. Biological Sciences - Medical Sciences: Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells. Fri, 27 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-141 Tento týden v Science: RIZIKO PRION ZOONÓZ: Priony jsou smrtelné infekční patogeny, které způsobují neurodegenerativní onemocnění lidí a zvířat. Mohou přecházet z jednoho druhu na jiný, ale s většími obtížemi, něž přenos v rámci stejného druhu. Patří mezi ně endemická scrapie ovcí a koz, chronické chřadnutí jelenů a losů (CWD) a bovinní spongiformní encefalopatie (BSE) neboli „nemoc šílených krav“. Béringue et al. ukazuje, že u transgenních myší s ovčím nebo lidským prionovým proteinem (PrP) jsou lymfatické tkáně náchylnější na křížové druhy přenosu než nervové tkáně (mozek), což může podmínit přehodnocení účinnosti druhových bariér. USNADNĚNÍ PŘENOSU PRIONŮ V EXTRANEURÁLNÍ TKÁNĚ U CROSS-DRUHŮ: Priony jsou infekční patogeny skládající se z PrPSc, složené podobně jako host-kódované PrPC prionového proteinu. Vědci porovnali schopnost mozku a lymfatické tkáně ovcí a lidské PrP u transgenní myši. Lymfatické tkáně jsou tolerantnější než je mozek vůči prionům, jako jsou ty, které způsobují chronické chřadnutí a bovinní spongiformní encefalopatii. Kromě toho, když byl přenos bariérou překonán napětím posunu v mozku, různí zástupci se šíří ve slezině a tím dochází k schopnosti nakazit i původního hostitele. Tak prion cross-druh přenosu ukazuje účinnost výraznou závislosti na tkáni. Fri, 27 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-214 Articles in this issue: Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2. Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity. The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation. Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease. Fri, 27 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-298 Články v tomto čísle: PŘEHLEDY: Strategie antiagregační léčby po perkutánní koronární intervenci. Potenciálně nevhodná (riziková) léčiva u seniorů: Expertní konsensus pro Českou republiku 2012. Některé celospolečenské náklady způsobené alkoholem. Z RŮZNÝCH OBORŮ: Primární prevence v ordinaci všeobecného praktického lékaře. Současná role endoskopické ultrasonografie v diagnostice nemocí slinivky břišní - vlastní zkušenosti. Výskyt rizikových faktorů kardiovaskulárních onemocnění u lidí cvičících jógu ve srovnání s běžnou populací. Průzkum motivačních faktorů u nelékařských zdravotnických pracovníků. Zneužívání psychoaktivních látek a diabetes mellitus. HISTORIE/FEJETON: Jan Jessenius, lékař umírajícího času. Antonín Spilka, pražský a bratislavský anatom. Fri, 27 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-137 Articles in this issue: INSIDE BLOOD: When a little aspirin may be enough. BLOOD WORK: Peripheral hemophagocytosis in malaria infection. CLINICAL TRIALS AND OBSERVATIONS: Administration of bortezomib before and after autologous stem cell transplantation improves outcome in multiple myeloma patients with deletion 17p. Safety of anticoagulants in children with arterial ischemic stroke. GENE THERAPY: AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage. IMMUNOBIOLOGY: TLR3 essentially promotes protective class I–restricted memory CD8+ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients. Thu, 26 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-139 This week in Nature: NEWS & VIEWS: Social science: Hunter-gatherer cooperation. Laser science: Even harder X-rays. Technology: A deeper peek into living organisms. Drug discovery: Chemical beauty contest. Nanotechnology: Shape matters. ARTICLES: Endothelial and perivascular cells maintain haematopoietic stem cells. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Thu, 26 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-142 Articles in this issue: Neoadjuvant Chemotherapy and Bevacizumab for HER2-Negative Breast Cancer - "Bevacizumab added to neoadjuvant combination chemotherapy increased the rate of pathological complete response among patients with HER-2-negative early-stage breast cancer. The effect was greatest in patients with the poorest prognosis, those with so-called triple-negative tumors". Bevacizumab Added to Neoadjuvant Chemotherapy for Breast Cancer - "The addition of bevacizumab to neoadjuvant combination chemotherapy significantly increased the percentage of patients with a pathological complete response. The effect was stronger in the estrogen-receptor–positive subgroup than in the hormone-receptor–negative subgroup". Lifetime Risks of Cardiovascular Disease - "Data from more than 250,000 men and women in 18 cohort studies were used to calculate the lifetime risk of cardiovascular events, stratified according to risk-factor burden, with adjustment for the competing risk of death from noncardiovascular causes". Thu, 26 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-147 Articles in this issue: ORIGINAL CONTRIBUTIONS: Lansoprazole for Children With Poorly Controlled Asthma: A Randomized Controlled Trial. Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer. Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds. MEDICAL NEWS & PERSPECTIVES: Treatment Rather Than Avoidance May Be Within Reach for Children With Food Allergies. Breast Cancer Symposium Highlights Risk, Recurrence, and Research Trials. Wed, 25 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-101 Tue, 24 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-102 Tue, 24 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-107 Tue, 24 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-100 Mon, 23 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-94 This week in Lancet: WORLD REPORT: India reports cases of totally drug-resistant tuberculosis. Germany's hospital doctors prepare to strike en masse. ARTICLES: Efficacy and safety of an extended nevirapine regimen in infant children of breastfeeding mothers with HIV-1 infection for prevention of postnatal HIV-1 transmission (HPTN 046): a randomised, double-blind, placebo-controlled trial. The natural history of self-harm from adolescence to young adulthood: a population-based cohort study. CLINICLA PICTURE: A stray bullet in the brain. REVIEW: Mental health of displaced and refugee children resettled in high-income countries: risk and protective factors. Sat, 21 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-206 Articles in this issue: RESEARCH: Effectiveness of strategies incorporating training and support of traditional birth attendants on perinatal and maternal mortality: meta-analysis. Timing of onset of cognitive decline: results from Whitehall II prospective cohort study. Short term outcomes of prostate biopsy in men tested for cancer by prostate antigen: prospective evaluation within ProtecT study. ANALYSIS: Evidence and desperation in off-label prescribing: recombinant factor VIIa. Sat, 21 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-97 This week in Science: NEWS & ANALYSIS: SEISMOLOGY: A Tantalizing View of What Set Off Japan's Killer Quake - "Japanese scientists combing through the vast jumble of seismic signals recorded in the days before the Tohoku earthquake have just sorted out more than 1000 newly recognized earthquakes". BIOFUELS: Engineered Superbugs Boost Hopes of Turning Seaweed Into Fuel - "In this week's issue of Science, researchers describe a strain of Escherichia coli that they have genetically engineered to break down and ferment alginate and all the other major sugars in seaweed into ethanol". CLINICAL TRIALS: Experimental Cancer Therapies Move to the Front Line - "It's standard to test drugs in advanced cancer; now, some doctors are using experimental drugs earlier in disease and juggling the challenges that come with doing so". Fri, 20 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-93 Articles in this issue: INSIDE BLOOD: Functional transfer of microRNA by exosomes. BLOOD WORK: Pseudo-Auer rods in a patient with newly diagnosed IgG myeloma. CLINICAL TRIALS AND OBSERVATIONS: Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients. A retrospective multicenter analysis of elderly Hodgkin lymphoma: outcomes and prognostic factors in the modern era. GENE THERAPY: CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo. HEMATOPOIESIS AND STEM CELLS: Expansion of functionally defined mouse hematopoietic stem and progenitor cells by a short isoform of RUNX1/AML1. Thu, 19 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-95 Articles in this issue: RESEARCH - NEWS & VIEWS: Materials science: A fresh twist for self-assembly. Evolutionary biology: A ratchet for protein complexity. Cell cycle: A division duet. Cancer: Reprogramming clinical outcome. ARTICLES: A novel retinoblastoma therapy from genomic and epigenetic analyses. Structure of HDAC3 bound to co-repressor and inositol tetraphosphate. Thu, 19 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-96 This week in PNAS: BIOLOGICAL SCIENCES: Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. BIOCHEMISTRY: Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1. MEDICAL SCIENCES: Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis. GENETICS: Two surfaces on the histone chaperone Rtt106 mediate histone binding, replication, and silencing. NEUROSCIENCE: Evolutionary conservation of the habenular nuclei and their circuitry controlling the dopamine and 5-hydroxytryptophan (5-HT) systems. Thu, 19 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-98 Articles in this issue: REVIEW ARTICLE: Current Concepts: Cognitive and Neurologic Outcomes after Coronary-Artery Bypass Surgery - "For patients undergoing coronary-artery bypass grafting (CABG), adverse neurologic outcomes, including stroke and cognitive decline, are major concerns. Even mild cognitive deficits before surgery may be a marker for cerebrovascular disease and increased risk". IMAGES IN CLINICAL MEDICINE: Pulmonary Cement Embolism after Vertebroplasty - "A 61-year-old man with spinal cord compression underwent therapeutic laminectomy of the fifth vertebra and laminectomy and vertebroplasty of the fourth vertebra. During the vertebroplasty, polymethylmethacrylate cement leaked into the paravertebral vascular system". Thu, 19 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-146 Articles in this issue: ORIGINAL CONTRIBUTIONS: Survival Without Disability to Age 5 Years After Neonatal Caffeine Therapy for Apnea of Prematurity. CLINICAL REVIEW: Symptomatic In-Hospital Deep Vein Thrombosis and Pulmonary Embolism Following Hip and Knee Arthroplasty Among Patients Receiving Recommended Prophylaxis: A Systematic Review. MEDICAL NEWS & PERSPECTIVES: Research Yields New Insights Into Mechanisms and Treatment of Pain. Poisonings Top Crashes for Injury-Related Deaths. GLOBAL HEALTH: Pneumonia Care for Children. HIV Trial Modification. Wed, 18 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-162 Articles in this issue: CELLULAR IMMUNOLOGY AND IMMUNE REGULATION: Histamine H4 Receptor Optimizes T Regulatory Cell Frequency and Facilitates Anti-Inflammatory Responses within the Central Nervous System. Leukocyte-Associated Ig-like Receptor-1–Deficient Mice Have an Altered Immune Cell Phenotype. Helminth Protection against Autoimmune Diabetes in Nonobese Diabetic Mice Is Independent of a Type 2 Immune Shift and Requires TGF-β. Regulatory T Cells Enhance Mast Cell Production of IL-6 via Surface-Bound TGF-β. MOLECULAR AND STRUCTURAL IMMUNOLOGY: Structural Insights into the Substrate Specificity of Human Granzyme H: The Functional Roles of a Novel RKR Motif. Upregulation of IL-23 Expression in Patients with Chronic Hepatitis B Is Mediated by the HBx/ERK/NF-κB Pathway. Sun, 15 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-89 This week in Lancet: WORLD REPORT: Republican presidential candidates united on health care. Grassroots project shines hope on Nairobi slum life. Pro-anorexia websites pose public health challenge. PERSPECTIVES: The body in question. Victorian values. The short life of a race drug. ARTICLES: Chemotherapy and human chorionic gonadotropin concentrations 6 months after uterine evacuation of molar pregnancy: a retrospective cohort study. Comparison of annual versus twice-yearly mass azithromycin treatment for hyperendemic trachoma in Ethiopia: a cluster-randomised trial. CLINICAL PICTURE: A free-floating left atrial mass. Sat, 14 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-207 Articles in this issue: RESEARCH: Possible net harms of breast cancer screening: updated modelling of Forrest report. Overdiagnosis from non-progressive cancer detected by screening mammography: stochastic simulation study with calibration to population based registry data. ANALYSIS: The idolatry of the surrogate. VIEWS & REVIEWS: Commercialisation is bad for public health. Sat, 14 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-90 Articles in this issue: NEWS & ANALYSIS: Tobacco Scientist's Election Tars Academy's Image. A Quick (Partial) Fix for an Ailing Atmosphere. NEWS FOCUS: The Peopling of the Aleutians. New Lease for Leftover Light. PERSPECTIVES: Ecology: Biodiversity and Ecosystem Function. Astronomy: Gamma-Ray Binaries Revealed. Chemistry: An Elusive Intermediate Gets Caught. Cell Biology: Sheddase Gets Guidance. Fri, 13 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-212 Article in this issue: Prognostic value of CD34+ peak in peripheral blood during mobilization in intermediate-risk AML patients treated in first CR by autologous or allogeneic transplantation. CORD BLOOD STEM CELL: Unrelated cord blood transplantation for thalassaemia: a single-institution experience of 35 patients. POST-TRANSPLANT EVENTS: Outcome of children requiring intensive care following haematopoietic SCT for primary immunodeficiency and other non-malignant disorders. ALLOGRAFTING: Reduced-intensity allogeneic hematopoietic cell transplantation using fludarabine–melphalan conditioning for treatment of mature T-cell lymphomas. Fri, 13 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-87 This week in PNAS: PHYSCIAL SCIENCES: Safe storage and effective monitoring of CO2 in depleted gas fields. GENETICS: Gene order and chromosome dynamics coordinate spatiotemporal gene expression during the bacterial growth cycle. ENVIROMENTAL SCIENCES: Unexpectedly high mortality in Pacific herring embryos exposed to the 2007 Cosco Busan oil spill in San Francisco Bay. IMMUNOLOGY: Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. MEDICAL SCIENCES: Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents. Thu, 12 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-88 Article in this issue: RESEARCH - NEWS & VIEWS: Biomechanics: Leaping lizards and dinosaurs. Applied physics: Nanowire electronics comes of age. Earth science: Limits of the power law. Astrophysics: Progenitors of type Ia supernovae. ARTICLE: The genetic basis of early T-cell precursor acute lymphoblastic leukaemia - "This work shows that treatments used for acute myeloid leukaemia and targeted therapies could be used for early T-cell precursor acute lymphoblastic leukaemia". Thu, 12 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-91 Articles in this issue: PERSPECTIVE: Expanding Eligibility, Cutting Costs — A Medicaid Update - "Medicaid programs are experiencing turbulence and imposing more spending cuts, most commonly through provider-payment reductions. Simultaneously, many are expanding their contracts with managed-care plans and preparing for health care reform's coverage expansion". SPECIAL ARTICLE: Fitness Memberships and Favorable Selection in Medicare Advantage Plans - "Medicare Advantage plans receive capitated payments and may benefit from enrolling healthier people. This study showed that after plans introduced fitness benefits, new enrollees reported better health status than those who had enrolled before the benefit was added". CLINICAL IMPLICATIONS OF BASIC RESEARCH: Diet and Intestinal Immunity - "Cruciform vegetables may be critical to intestinal health and immunity. It turns out that these vegetables contain ligands of the aryl hydrogen receptor which, when bound, turn on genes that mediate intestinal immune defense". Thu, 12 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-92 Article in this issue: INSIDE BLOOD: The beauty of TLR agonists for CTCL. REVIEW ARTICLE: Prognostic and therapeutic implications of minimal residual disease detection in acute myeloid leukemia. CLINICAL TRIALS AND OBSERVATIONS: Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia. In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study. Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies. GENE THERAPY: Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity. HEMATOPOIESIS AND STEM CELLS: Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia. Thu, 12 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-145 Articles in this issue: ORIGINAL CONTRIBUTIONS: Serum Potassium Levels and Mortality in Acute Myocardial Infarction. Association of Incident Dementia With Hospitalizations. Association Between Marijuana Exposure and Pulmonary Function Over 20 Years. CLINICAL REVIEW: Prognostic Indices for Older Adults: A Systematic Review. MEDICAL NEWS & PERSPECTIVES: New Reports Examine Psychiatric Risks of Varenicline for Smoking Cessation. Expert Panel Advocates Surveillance for Men With Low-Risk Prostate Cancer. Wed, 11 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-76 This week in Lancet: WORLD REPORT: Legalise assisted suicide, UK Commission urges. Haiti prepares for cholera vaccination but concerns remain. Prescription drug addiction: the treatment challenge. PERSPECTIVES: Anatomy of an artist. The rise, fall, and revival of recovery in drug policy. Sat, 07 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-208 Articles in this issue: RESEARCH: Effect of reporting bias on meta-analyses of drug trials: reanalysis of meta-analyses. Publication of NIH funded trials registred in ClinicalTrials.gov: cross sectional analysis. Assessment of publication bias, selection bias and unavailable data in meta-analyses using individual participant data: a database survey. Understanding why evidence from randomised clinical trials may not be retrieved from Medline: comparison of indexed and non-indexed records. Impact of document type on reporting quality of clinical drug trials: a comparison of registry reports, clinical study reports, and journal publications. Sat, 07 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-75 Articles in this issue: MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs during ESC Differentiation. Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells. Diazepam Binding Inhibitor Promotes Progenitor Proliferation in the Postnatal SVZ by Reducing GABA Signaling. Fri, 06 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-82 This week in Science: NEWS & ANALYSIS: Will Flu Papers Lead to New Research Oversight? - "At the request of the National Science Advisory Board for Biosecurity, Science and Nature have agreed to strike key details from papers in press describing how researchers made the deadly H5N1 avian influenza virus more transmissible between mammals". Laser Fusion Project Alters Goals, Fueling Concern Over Its Strategy - "A change in the milestones of the National Ignition Facility has highlighted the concerns of some in the field that the path NIF researchers have taken may not be the right one". NEWS FOCUS: Unraveling the Obesity-Cancer Connection - "A growing body of research shows that insulin and a related hormone play a key role in fueling tumors. They also may be a link between obesity, diabetes, and cancer". Fri, 06 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-84 This week in PNAS: RESEARCH ARTICLES: Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation. PHYSICAL SCIENCES: Characterization and adaptive optical correction of aberrations during in vivo imaging in the mouse cortex. CHEMISTRY: Photo-ribonucleotide reductase β2 by selective cysteine labeling with a radical phototrigger. Low temperature formation of naphthalene and its role in the synthesis of PAHs (Polycyclic Aromatic Hydrocarbons) in the interstellar medium. Fri, 06 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-74 Articles in this issue: INSIDE BLOOD: Two genes, tipifarnib, and AML. The Serenity Prayer for acute GVHD. BLOOD WORK: Accelerated phase of Chediak-Higashi syndrome. CLINICAL TRIALS AND OBSERVATIONS: The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis. Immunoglobulin D amyloidosis: a distinct entity. Risk factors for acute GVHD and survival after hematopoietic cell transplantation. HEMATOPOIESIS AND STEM CELLS: Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells. Thu, 05 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-85 This week in NEJM: ORIGINAL ARTICLES: Rivaroxaban in Patients with a Recent Acute Coronary Syndrome - "In patients with acute coronary syndromes, low doses of rivaroxaban were effective in reducing the primary end point of death from cardiovascular causes, myocardial infarction, or stroke. Rivaroxaban also reduced overall mortality, although there was more bleeding". Efficacy Results of a Trial of a Herpes Simplex Vaccine - "There is no vaccine to prevent herpes simplex virus (HSV) infection. In this trial in 8323 women, a candidate HSV vaccine containing glycoprotein D was found to be ineffective in preventing HSV-2 infection". Thu, 05 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-86 Articles in this issue: A sensing array of radically coupled genetic ‘biopixels’ - "Thousands of quorum-sensing Escherichia coli colonies are synchronized over centimetres using redox signalling to create ‘biopixels’ that can sense trace amounts of arsenic in water". Antiparallel EmrE exports drugs by exchanging between asymmetric structures - "NMR and single molecule FRET experiments show that antiparallel EmrE dimers interconvert between two identical but oppositely oriented conformations that are each open only to one side of the membrane". NEWS & VIEWS: Synthetic biology: Bacteria collaborate to sense arsenic. Astrophysics: The final plunge. Neuroscience: Behavioural effects of cocaine reversed. Thu, 05 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-158 Articles in this issue: CLINICAL REVIEWS IN ALLERGY AND IMMUNOLOGY: Respiratory health effects of air pollution: Update on biomass smoke and traffic pollution. CONTINUING MEDICAL EDUCATION EXAMINATION: Respiratory health effects of air pollution: Update on biomass smoke and traffic pollution. MECHAMISM OF ALLERGIC DISEASES: Effects of air pollutants on innate immunity: The role of Toll-like receptors and nucleotide-binding oligomerization domain–like receptors. ATOPIC DERMATITIS AND SKIN DISEASE: Corticotropin-releasing hormone downregulates IL-10 production by adaptive forkhead box protein 3–negative regulatory T cells in patients with atopic dermatitis. Thu, 05 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-143 Articles in this issue: ORIGINAL CONTRIBUTIONS: Effect of Dietary Protein Content on Weight Gain, Energy Expenditure, and Body Composition During Overeating: A Randomized Controlled Trial. Bariatric Surgery and Long-term Cardiovascular Events. International Variation in and Factors Associated With Hospital Readmission After Myocardial Infarction. CLINICAL CROSSROADS: Management of Needlestick Injuries: A House Officer Who Has a Needlestick. MEDICAL NEWS & PERSPECTIVES: Scientists, Officials Eye Tools Aimed at Combating Abuse of Painkillers. Researchers Still Seek Clinical Benefit in Raising Levels of Good Cholesterol. FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION: Licensure of a Meningococcal Conjugate Vaccine for Children Aged 2 Through 10 Years and Updated Booster Dose Guidance for Adolescents and Other Persons at Increased Risk for Meningococcal Disease—Advisory Committee on Immunization Practices (ACIP), 2011. Wed, 04 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-52 Articles in this issue: REVIEWS: Survivin: A Dual Player in Healthy and Diseased Skin. Cholinergic Regulation of Keratinocyte Innate Immunity and Permeability Barrier Integrity: New Perspectives in Epidermal Immunity and Disease. CELL BIOLOGY: Interferon Regulatory Factor 6 Is Necessary, but Not Sufficient, for Keratinocyte Differentiation. Ryanodine Receptors Are Expressed in Epidermal Keratinocytes and Associated with Keratinocyte Differentiation and Epidermal Permeability Barrier Homeostasis. CLINICAL RESEARCH: Can We Rely on the Dermatology Life Quality Index as a Measure of the Impact of Psoriasis or Atopic Dermatitis?. Mon, 02 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-51 Articles in this issue: REVIEW ARTICLES: Hematopoietic progenitor cells are innate Th2 cytokine-producing cells (pages 4–9). EXPERIMENTAL ALLERGY AND IMMUNOLOGY: Differential expression of interleukin-32 in chronic rhinosinusitis with and without nasal polyps. Differential expression of interleukin-32 in chronic rhinosinusitis with and without nasal polyps. Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells. EPIDEMIOLOGY AND GENETICS: Asthma in adults and its association with chronic rhinosinusitis: The GA2LEN survey in Europe. IMMUNODEFICIENCES: Target levels of functional C1-inhibitor in hereditary angioedema. Mon, 02 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-77 Articles in this issue: NEWS AND VIEWS: Spliceosome mutations in hematopoietic malignancies. Following evolution of bacterial antibiotic resistance in real time. ARTICLES: Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm. Dnmt3a is essential for hematopoietic stem cell differentiation. Mon, 02 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-78 Articles in this issue: REVIEWS: Epithelial cell polarity, stem cells and cancer - "The regulation of cell polarity has pleiotropic effects on cell morphology and function, which has implications for tumorigenesis and tumour progression. This Review discusses how polarity complexes affect tumour cell biology and their crosstalk with other important cancer pathways". PERSPECTIVES: Safe harbours for the integration of new DNA in the human genome - "Human cell engineering has made considerable progress, but where to insert foreign sequences in the human genome to maximize safety and efficacy is still uncertain. This Opinion article discusses genomic safe harbours, which are chromosomal locations where therapeutic transgenes can integrate and function without perturbing endogenous gene activity or promoting cancer". Mon, 02 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-79 This month in NRG: PROGRESS: Uncovering the role of 5-hydroxymethylcytosine in the epigenome - "The recent discovery of enzymes that convert 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) in mammalian genomes has led to a surge of interesting possible functions for 5hmC, from the regulation of DNA methylation to the biology of pluripotency, differentiation and brain function". Genomically humanized mice: technologies and promises - "This article describes the promising technologies for generating humanized mouse models — that is, mouse strains containing large sections of human coding and non-coding sequences — for the purposes of improving our understanding of basic genome function and disease and discovering effective therapies". REVIEWS: Emerging biomedical applications of synthetic biology. Mon, 02 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-80 This month in NRI: REVIEWS: The impact of perinatal immune development on mucosal homeostasis and chronic inflammation - "In this Review article, the authors describe the perinatal development of intestinal and respiratory mucosal immune systems. Moreover, they discuss how environmental factors, such as the neonatal composition of commensal bacteria, can affect the maturation of mucosal immune systems, leading to the development of chronic inflammatory disorders later in life". Molecular programming of B cell memory - "Understanding the molecular events that orchestrate the formation of high-affinity memory B cells will help to improve vaccination strategies. In this Review article, McHeyzer-Williams and colleagues discuss the cellular and molecular interactions that regulate commitment to B cell memory, the germinal centre reaction and the generation of memory plasma cells following antigen recall". The role of ubiquitylation in immune defence and pathogen evasion. PERSPECTIVES: Experimental mouse tumour models: what can be learnt about human cancer immunology? Mon, 02 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-81 Articles in this issue: RESEARCH: Effect of androgen treatment during foetal and/or neonatal life on ovarian function in prepubertal and adult rats. Fibroblast growth factor 2 is a key determinant of vascular sprouting during bovine luteal angiogenesis. Differential marker protein expression specifies rarefaction zone-containing human Adark spermatogonia. Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in the release of foetal membranes. Mechanism of action of inhibin on development of ovarian granulosa cells in the mouse by means of RNA interference of inhibin α-subunit gene. Mon, 02 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-83 Articles in this issue: Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study. Efficacy and safety of once daily elvitegravir versus twice daily raltegravir in treatment-experienced patients with HIV-1 receiving a ritonavir-boosted protease inhibitor: randomised, double-blind, phase 3, non-inferiority study. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Predictive value of interferon-γ release assays for incident active tuberculosis: a systematic review and meta-analysis. REVIEW: Malaria in pregnancy in the Asia-Pacific region. Mon, 02 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-209 Články v tomto čísle: PŮVODNÍ PRÁCE: Katétrová infekce krevního řečiště - prevalence a intervence. Kombinace statin - ezetimib v léčbě hyperlipidémie. SPECIÁLNÍ SDĚLENÍ: Predikce v medicíně - genom contra envirom. DĚJINY LÉKAŘSTVÍ: Lékařství v antickém starověku. Mon, 02 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2012#m01 jurnal-164 Articles in this issue: CELLULAR IMMUNOLOGY AND IMMUNE REGULATION: IDO and Regulatory T Cell Support Are Critical for Cytotoxic T Lymphocyte-Associated Ag-4 Ig-Mediated Long-Term Solid Organ Allograft Survival. Direct Reduction of Antigen Receptor Expression in Polyclonal B Cell Populations Developing In Vivo Results in Light Chain Receptor Editing. Protein Energy Malnutrition Impairs Homeostatic Proliferation of Memory CD8 T Cells. Arthritogenic Self-Reactive CD4+ T Cells Acquire an FR4hiCD73hi Anergic State in the Presence of Foxp3+ Regulatory T Cells. IMMUNOGENETICS: Fundamental Characteristics of the Immunoglobulin VH Repertoire of Chickens in Comparison with Those of Humans, Mice, and Camelids. INFLAMMATION: Adenosine Augments IL-10 Production by Microglial Cells through an A2B Adenosine Receptor-Mediated Process. Sun, 01 Jan 2012 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-110 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-111 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-112 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-113 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-114 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-115 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-116 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-117 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-150 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-161 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-166 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-169 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-215 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-246 Sat, 31 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-65 Articles in this issue: PERSPECTIVE: The Savings Illusion — Why Clinical Quality Improvement Fails to Deliver Bottom-Line Results - "Many people believe that improving clinical quality — reducing readmissions, shortening lengths of stay, and building efficiency into clinical processes — will reduce health care costs. So why haven't years of work in quality improvement had a measurable effect on costs?". CLINICAL IMLICATIONS OF BASIC RESEARCH: Diabetic Stem-Cell “Mobilopathy” - "Obtaining hematopoietic stem cells (HSCs) for transplantation depends on effective egress of HSCs from bone marrow into the peripheral circulation on induction. This process is impaired in a mouse model of diabetes and in patients undergoing autologous transplantation". Thu, 29 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-152 Articles in this issue: ORIGINAL CONTRIBUTIONS: ADHD Medications and Risk of Serious Cardiovascular Events in Young and Middle-aged Adults. Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction. CLINICAL REVIEW: CYP2C19 Genotype, Clopidogrel Metabolism, Platelet Function, and Cardiovascular Events: A Systematic Review and Meta-analysis. MEDICAL NEWS & PERSPECTIVES: NIH’s Undiagnosed Diseases Program Reports on Successes, Challenges. IOM: Health IT Needs Better Oversight. Wed, 28 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-73 This week in PNAS: BIOLOGICAL SCIENCES: Hunter–gatherers and other primates as prey, predators, and competitors of snakes. MEDICAL SCIENCES: Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. PHYSICAL SCIENCES: Large-area optoelastic manipulation of colloidal particles in liquid crystals using photoresponsive molecular surface monolayers. ENGINEERING: Curvature-driven capillary migration and assembly of rod-like particles. Tue, 27 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-57 In this issue: PREVIEWS: Food for Thought: Linking Caloric Intake to Behavior via Sirtuin Activity. Transcription and mRNA Stability: Parental Guidance Suggested. ARTICLES: SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive. A Poised Chromatin Platform for TGF-β Access to Master Regulators. Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution. Interaction between Differentiating Cell- and Niche-Derived Signals in Hematopoietic Progenitor Maintenance. SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1. Fri, 23 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-69 This week in Science: NEWS & ANALYSIS: Tissue Says Blood Is Misleading, Confusing HIV Cure Efforts - "A recent meeting provided fresh insights into why HIV is so difficult to eliminate from the body: Even when antiretroviral drugs knock down HIV to undetectable levels in blood, the virus remains active in tissues". New Hope for a Devastating Neurological Disorder - "Scientists have identified a drug that, in mice, fixes the genetic defect behind Angelman syndrome, which robs victims of speech and leaves them with intellectual disabilities, movement and balance problems". NEWS FOCUS: Preserving History, One Hill at a Time - "Ancient settlements in what is now Louisiana may have laid the foundation not only for the great city of Cahokia but perhaps also for Mesoamerican civilization". Fri, 23 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-218 Articles in this issue: The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation. Control of B Cell Development by the Histone H2A Deubiquitinase MYSM1. Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome. Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment. Th17 Cells Mediate Clade-Specific, Serotype-Independent Mucosal Immunity. Fri, 23 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-55 Articles in this issue: INSIDE BLOOD: Enigmatic variation. Predicting cytokine storms: it's about density. A cofactor for factor XI activation. REVIEW ARTICLES: Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. CLINICAL TRIALS AND OBSERVATIONS: Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category. HEMATOPOIESIS AND STEM CELLS: Dual functions of cell-autonomous and non–cell-autonomous ADAM10 activity in granulopoiesis. Thu, 22 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-64 Articles in this issue: PERSPECTIVE: Global Health: Facing a “Slow-Motion Disaster” — The UN Meeting on Noncommunicable Diseases - "In September, representatives from 192 countries met at a UN conference on noncommunicable diseases, turning international attention from the devastation wrought by well-known epidemics such as those of AIDS and malaria to a quieter, though no less dangerous, threat". REVIEW ARTICLE: Medical Progress: Focal Segmental Glomerulosclerosis - "Focal segmental glomerulosclerosis, which is characterized by progressive glomerular scarring, accounts for about 20% of cases of the nephrotic syndrome in children and 40% in adults. This review considers current approaches to diagnosis and management of the disease". CLINICAL PRACTICE: Primary Hyperparathyroidism - "This article reviews the differential diagnosis and management of primary hyperparathyroidism. For most patients, parathyroidectomy (usually by a minimally invasive approach) is recommended, but surveillance is an option for asymptomatic patients who meet certain criteria". Thu, 22 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-151 Articles in this issue: ORIGINAL CONTRIBUTIONS: Sleep Disorders, Health, and Safety in Police Officers. Temporal Changes in Resting Heart Rate and Deaths From Ischemic Heart Disease. Association Between Chlorthalidone Treatment of Systolic Hypertension and Long-term Survival. MEDICAL NEWS & PERSPECTIVES: Policy Paper Highlights Concerns About the Future of HIV Care and Its Funding. GLOBAL HEALTH: Community Protection From Pneumococcus Infection. Reducing Indoor Air Pollution. Genetic Susceptibility to Dengue. Wed, 21 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-72 This week in PNAS: BIOCHEMISTRY: Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast. MEDICAL SCIENCES: Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells. NEUROSCIENCE: Deficits in reach target selection during inactivation of the midbrain superior colliculus. PLANT BIOLOGY: Organelle–nucleus cross-talk regulates plant intercellular communication via plasmodesmata. Tue, 20 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-60 This week in Lancet: ARTICLES: Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Bedside detection of awareness in the vegetative state: a cohort study. Foley catheter versus vaginal prostaglandin E2 gel for induction of labour at term (PROBAAT trial): an open-label, randomised controlled trial. CLINICAL PICTURE: Abdominal calcifications. REVIEW: Anaemia in low-income and middle-income countries. Sat, 17 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-68 This week in Science: NEWS & ANALYSIS: U.K. to Open Health Records as E.U. Considers Restrictions - "A new British proposal to make health data more available to scientists may run smack into the European Union, which is exploring revisions to its data-protection guidelines". China Bets on the Variome to Uncover Hereditary Diseases - "China is contributing 3 billion yuan ($470 million) to the Human Variome Project, an international effort to catalog gene variations affecting human health". NEWS FOCUS: Taking a New Shot At a TB Vaccine - "Eager to replace the current tuberculosis vaccine, scientists hope to push a slew of promising candidates through clinical trials—if the money can be found". Fri, 16 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-54 Articles in this issue: INSIDE BLOOD: Multiple distinct NK-cell synapses. Finally, a transgenic light chain amyloidosis mouse model. Humoral HLA sensitization matters in CBT outcome. BLOOD WORK: Persistent polyclonal B-cell lymphocytosis. REVIEW ARTICLES: The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells. CLINICAL TRIALS AND OBSERVATIONS: Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danish population-based cohort study. Mechanism of catheter thrombosis: comparison of the antithrombotic activities of fondaparinux, enoxaparin, and heparin in vitro and in vivo. Thu, 15 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-63 Articles in this issue: PERSPECTIVE: Needed: Pragmatic Clinical Trials for Statin-Intolerant Patients - "Statins have adverse effects, but it's difficult to design randomized trials of alternative therapies for statin-intolerant patients. Pragmatic clinical trials, performed in the context of usual care with broad eligibility criteria, are well suited to this purpose". The Risks and Benefits of Indacaterol — The FDA's Review - "In July, the FDA approved Arcapta Neohaler (indacaterol maleate powder), a long-acting beta-agonist, at a daily dose of 75 μg for chronic obstructive pulmonary disease. Why was this dose selected, after the European Medicines Agency approved 150-μg and 300-μg doses?". SPECIAL ARTICLE: The Relationship between Hospital Admission Rates and Rehospitalizations - "Hospital readmission rates are thought to reflect the quality of transitional care. In this study, readmission rates for congestive heart failure and pneumonia were associated with overall hospitalization rates. Interventions may best be focused on reducing incentives to use hospital services". Thu, 15 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-167 Articles in this issue: CELLULAR IMMUNOLOGY AND IMMUNE REGULATION: CARMA1 Is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma. Redox Remodeling by Dendritic Cells Protects Antigen-Specific T Cells against Oxidative Stress. Neutralizing IL-6 Reduces Human Arterial Allograft Rejection by Allowing Emergence of CD161+ CD4+ Regulatory T Cells. Granzyme B Regulates Antiviral CD8+ T Cell Responses. Transfer of Regulatory Properties from Tolerogenic to Proinflammatory Dendritic Cells via Induced Autoreactive Regulatory T Cells. MOLECULAR AND STRUCTURAL IMMUNOLOGY: Structural Basis of Diverse Peptide Accommodation by the Rhesus Macaque MHC Class I Molecule Mamu-B*17: Insights into Immune Protection from Simian Immunodeficiency Virus. Stable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug Design. Thu, 15 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-149 Articles in this issue: ORIGINAL CONTRIBUTIONS: Causes of Death Among Stillbirths. Association Between Stillbirth and Risk Factors Known at Pregnancy Confirmation. Cancer Risk Among Patients With Myotonic Muscular Dystrophy. MEDICAL NEWS & PERSPECTIVES: Drug for Severe Sepsis Is Withdrawn From Market, Fails to Reduce Mortality. Outbreaks Spur Measles Vaccine Studies. FDA Grants Approval for First Cord Blood Product. CAPITOL HEALTH CALL: Price of Health Care Services. Insurers and Testing Laboratories. Wed, 14 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-71 This week in PNAS: CELL BIOLOGY: Separation of telomerase functions by reverse genetics. PHARMACOLOGY: Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds. APPLIED MATHEMATICS: Sparse linear modeling of next-generation mRNA sequencing (RNA-Seq) data for isoform discovery and abundance estimation. CHEMISTRY: The electrochemistry of quinizarin revealed through its mediated reduction of oxygen. Tue, 13 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-59 This week in Lancet: WORLD REPORT: India grapples with its child marriage challenge. PERSPECTIVES: Anand Grover: leading the defence of human rights. ARTICLES: Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study. Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20 536 high-risk individuals: a randomised controlled trial. Risk and causes of paediatric hospital-acquired bacteraemia in Kilifi District Hospital, Kenya: a prospective cohort study. CASE REPORT: Routine blood tests? Helping you live(r) longer! Sat, 10 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-56 In this issue: ANALYSIS: Virus Hunters: Catching Bugs in the Field. ARTICLES: Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans. Structural Basis for Promoter −10 Element Recognition by the Bacterial RNA Polymerase σ Subunit. Structural Basis for Promoter −10 Element Recognition by the Bacterial RNA Polymerase σ Subunit. THEORY: Katanin Contributes to Interspecies Spindle Length Scaling in Xenopus. Fri, 09 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-67 This week in Science: NEWS & ANALYSIS: Genes Confirm Europeans' Blow to Native Americans - "A study published this week concludes that about 500 years ago, the number of reproductively active Native American women quickly plunged by half, indicating a "widespread and severe" contraction in population size". Congress Asks NOAA to Consider Charging for Data - "Faced with soaring NOAA satellite costs and a bleak budget outlook, lawmakers last month ordered the agency to explore ways of charging users for its "specialized data products". NEWS FOCUS: HALTING HIV/AIDS Epidemics - "A slew of successes in clinical trials has elated the HIV prevention field, and models now suggest that combining them might virtually stop HIV's spread. But caveats abound". Fri, 09 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-53 Articles in this issue: INSIDE BLOOD: From the observation DAC: romidepsin revisited. Innovation in myeloma treatments PARP excellence!. REVIEWS ARTICLES: NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights. From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. CLINICAL TRIALS AND OBSERVATIONS: Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility. A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma. Thu, 08 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-62 Articles in this issue: CLINICAL PRACTICE: A Request for Abortion - "In early pregnancy, medical abortion avoids surgery but is associated with more pain and bleeding and a slightly higher risk of incomplete abortion. Data show that neither type of abortion increases the risk of long-term mental health problems or breast cancer or adversely affects fertility". REVIEW ARTICLE: Mechanisms of Disease: The Pathogenesis of Rheumatoid Arthritis - "The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality". Thu, 08 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-148 Articles in this issue: ORIGINAL CONTRIBUTIONS: Initiation of Tumor Necrosis Factor-α Antagonists and the Risk of Hospitalization for Infection in Patients With Autoimmune Diseases. Factors Associated With Treatment Response to Etanercept in Juvenile Idiopathic Arthritis. Association of Antenatal Corticosteroids With Mortality and Neurodevelopmental Outcomes Among Infants Born at 22 to 25 Weeks' Gestation. CLINICAL CROSSROADS: Antiplatelet and Anticoagulant Therapy in Patients With Gastrointestinal Bleeding: An 86-Year-Old Woman With Peptic Ulcer Disease. MEDICAL NEWS & PERSPECTIVES: Influential Groups Propose Less Frequent Cervical Cancer Screening for Most Women. Hospital Palliative Care Programs Raise Grade to B in New Report Card on Access. Wed, 07 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-70 This week in PNAS: GENETICS: Direct regulation of nucleosome density by the conserved AAA-ATPase Yta7. MEDICAL SCIENCES: Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. NEUROSCIENCE: FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders. APPLIED MATHEMATICS: The Voronoi Implicit Interface Method for computing multiphase physics. Tue, 06 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-160 Articles in this issue: CONTINUING MEDICAL EDUCATION EXAMINATION: Histamine and H1-antihistamines: Celebrating a century of progress. Regulation of the immune response and inflammation by histamine and histamine receptors. MECHANISM OF ALLERGIC DISEASES: Regulation of the immune response and inflammation by histamine and histamine receptors. ASTHMA AND LOWER AIRWAY DISEASE: Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence. FOOD, DRUG, INSECT STING ALLERGY, AND ANAPHYLAXIS: Allergic sensitization can be induced via multiple physiologic routes in an adjuvant-dependent manner. Soybean isoflavones regulate dendritic cell function and suppress allergic sensitization to peanut. Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. Tue, 06 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-58 This week in Lancet: WORLD REPORT: The Commission on Macroeconomics and Health: 10 years on. PERSPECTIVES: Health policy: from the clinical to the economic gaze. Revolution in health care. Stephen Lawrie: PsySTAR trek, the next generation. Stephen Lawrie: PsySTAR trek, the next generation. CLINICAL PICTURE: Spinal tuberculosis. CASE REPORT: What a difference an egg makes. Sat, 03 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-24 In this issue: On the cover: The cover is an artistic representation of the various different elements that interact to promote reprogramming of somatic cells to pluripotency. In this issue, Wang et al. (575–587) focus on the role of the histone demethylases Jhdm1a/1b. Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-26 David van Heel, Cisca Wijmenga and colleagues used a custom, high-density genotyping chip to examine 183 immune-related loci for their role in celiac disease. They report 13 new regions associated with celiac disease risk, identify multiple independent signals at several loci and refine the localization of many previously reported risk signals. Douglas Winton and colleagues report the results of a large insertional mutagenesis screen to identify drivers of intestinal tumorigenesis in mice. The study identifies a large number of potential cancer drivers, including new modifiers of canonical Wnt signaling and components of the FGF pathway. Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-28 In this issue: Reviews: Genetic contributions to behavioural diversity at the gene–environment interface - The authors review our understanding of how common genetic variation contributes to behavioural diversity, explaining how these variants modulate an organism's interaction with the environment and defining gene classes — such as those affecting sensory or neuromodulatory pathways — that are preferentially associated with behavioural variation. Controlling gene expression in response to stress - Organisms are exposed to various stresses, and responding rapidly and appropriately to these changes is crucial for survival. This Review describes how gene expression is regulated at many levels in response to stresses, including through signalling to chromatin or affecting transcriptional machinery. Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-30 In this issue: Reviews: TLR-dependent T cell activation in autoimmunity - Infection, tissue injury and alterations in the composition of the microbiota have been implicated in the initiation of autoimmune diseases. In this Review article, Kingston Mills discusses how Toll-like receptor (TLR) signalling downstream of all these events can regulate the function of autoreactive T cells both directly and indirectly (through the activation of innate immune cells), and comments on the therapeutic implications of TLR targeting. Towards a systems understanding of MHC class I and MHC class II antigen presentation - This article provides a broad, timely review of our current understanding of MHC class I and class II antigen presentation and presents a survey of 43 experts in the field on the most important outstanding issues. Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-34 První část prosincového čísla časopisu Allergy se zabývá alergiemi a imunologií. Je zde článek pojednávající o možnosti využití reakce specifických protilátek proti sekreční fosfolipidáze A2 (sPLA2) ve studiu crosreaktivity T-buněk. Další článek se dotýká problematiky ctrossreaktivity a to konkrétně mezi alergií na arašíky a na ostatní oříšky. V následujícím článku je zveřejněna studie zabývající se testováním pacientů se sennou rýmou a měření aktivace bazofilů po dlouhodobém podávání tablet obsahující pyl. V článku o žírných buňkách se dočteme o jejich roli u pacientů s chronickou kopřivkou. V další části časopisu jsou články týkající se genetiky. Najdeme zde například článek o vlivu variantě genu FCER2 na děti s astmatem léčeným steroidy, o PTGDR (Prostaglandin D2 receptor gen) a o studii zabývající se vlivem vystavení vlhkému prostředí a plísním v raném dětství a následným rozvojem alergií. V poslední části časopisu je článek o tom, jaký vliv má astma v kombinaci s dalšími chronickými onemocněními na dlouhodobou pracovní neschopnost pacientů. Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-36 Articles in this issue: CELL BIOLOGY: Myocardin-Related Transcription Factors A and B Are Key Regulators of TGF-β1-Induced Fibroblast to Myofibroblast Differentiation. GENETICS: Black Patients of African Descent and HLA-DRB1*15:03 Frequency Overrepresented in Epidermolysis Bullosa Acquisita ; Clinical, Molecular, and Cellular Features of Non-Puerto Rican Hermansky–Pudlak Syndrome Patients of Hispanic Descent. IMMUNOLOGY / INFECTION: IL-17A Upregulates Keratin 17 Expression in Keratinocytes through STAT1- and STAT3-Dependent Mechanisms ; Inter-Regulation of Th17 Cytokines and the IL-36 Cytokines In Vitro and In Vivo: Implications in Psoriasis Pathogenesis. Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-42 Reproduction publishes papers which focus on the cellular and molecular biology of reproduction. Emerging topics include cloning, the biology of embryonic stem cells, environmental effects on reproductive potential and health (e.g. obesity), and epigenetic effects on reproductive and developmental processes. Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-44 In this issue: Reviews: Choline metabolism in malignant transformation - Choline metabolism is commonly deregulated in cancer, leading to increased levels of choline metabolites. This Review discusses the deregulation of choline metabolism in cancer, its reciprocal interaction with oncogenic signalling and the possible clinical applications in diagnostics and therapy. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy - Many different microRNAs (miRNAs) have now been linked to cancer, but our understanding of the pathways that are regulated by these miRNAs in vivo is still limited. This Review discusses progress in using mouse models to understand the roles of miRNAs in cancer and the therapeutic potential of these molecules. Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-46 Articles in this issue: REVIEW: Antiviral resistance during the 2009 influenza A H1N1 pandemic: public health, laboratory, and clinical perspectives. COMMENT: Effects of malaria and its treatment in early pregnancy ; Global burden of food-borne trematodiasis. ARTICLES: Adverse effects of falciparum and vivax malaria and the safety of antimalarial treatment in early pregnancy: a population-based study ; Intermittent preventive therapy for malaria with monthly artemether–lumefantrine for the post-discharge management of severe anaemia in children aged 4–59 months in southern Malawi: a multicentre, randomised, placebo-controlled trial. Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-66 This week in Science: NEWS OF THE WEEK: Random Sample - "A new species of orchid has been discovered in the primeval tropical forest of the island of New Britain in Papua New Guinea that blooms at night. An Internet psychologist has identified four common characteristics of so-called viral videos". NEWS & ANALYSIS: Controversial Studies Give a Deadly Flu Virus Wings - "H5N1 avian influenza strains genetically altered to be more easily transmissible are the subject of a heated debate among scientists, biosecurity experts, and U.S. government officials". NEW FOCUS: Aging Genes: The Sirtuin Story Unravels - "Work that pinpointed the control of aging in a handful of genes is being taken apart by some of the scientists who made early discoveries. Efforts to replicate studies are producing conflicting results". Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-247 Články v tomto čísle: Ulcerogenita kortikoidů - přežívající mýtus mezi českými lékaři. Psychoterapeutický přístup v medicíně. Srovnávání metod DXA a BIA u obézních žen indikovaných ke sleeve gastrektomii - pilotní studie. Standardizace nutriční péče v domově pro seniory. Deficit objemu telových tekutín hodnotený sestrami podľa diagnostických znakov ošetrovateľskej diagnózy. Fri, 02 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-40 Articles in this issue: INSIDE BLOOD: It's all in the timing. BLOOD WORK: Plummer-Vinson syndrome and reactive thrombocytosis mask a JAK2-V617F positive myeloproliferative neoplasm. PLENARY PAPER: Prognostic relevance of 18-F FDG PET/CT in newly diagnosed multiple myeloma patients treated with up-front autologous transplantation. CLINICAL TRIALS AND OBSERVATIONS: Prognostic relevance of 18-F FDG PET/CT in newly diagnosed multiple myeloma patients treated with up-front autologous transplantation. Thu, 01 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-61 Articles in this issue: REVIEW ARTICLES: Genomic Medicine: Genomics of Cardiovascular Disease - "The authors provide an overview of how genetic and genomic studies have improved our understanding of the cause of cardiovascular disease". Mechanisms of Disease: Systemic Lupus Erythematosus - "The author reviews environmental, genetic, epigenetic, and hormonal factors in systemic lupus erythematosus, its diverse organ manifestations, and the myriad immune abnormalities that characterize this autodestructive disease, which mainly affects women of childbearing age". CLINICAL PROBLEM-SOLVING: A Hidden Solution - "A 51-year-old woman presented to the ER with a 6-month history of intermittent palpitations, which had worsened that day. She described her pulse as fast but regular. She also reported worsening fatigue, heat intolerance, and an 18-kg (40-lb) weight loss". Thu, 01 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m12 jurnal-165 Articles in this issue: CELLULAR IMMUNOLOGY AND IMMUNE REGULATION: Different Expression Levels of the TAP Peptide Transporter Lead to Recognition of Different Antigenic Peptides by Tumor-Specific CTL. Virally-Induced Upregulation of Heparan Sulfate on B Cells via the Action of Type I IFN. Quantifying Antigen-Specific CD4 T Cells during a Viral Infection: CD4 T Cell Responses Are Larger Than We Think. Human Th1 and Th17 Cells Exhibit Epigenetic Stability at Signature Cytokine and Transcription Factor Loci. MOLECULAR AND STRUCTURAL IMMUNOLOGY: Structure-Based Selection of Small Molecules To Alter Allele-Specific MHC Class II Antigen Presentation. The Actin Regulatory Protein HS1 Is Required for Antigen Uptake and Presentation by Dendritic Cells. IMMUNOGENETICS: A Comparative Analysis of Viral Peptides Presented by Contemporary Human and Chimpanzee MHC Class I Molecules. Thu, 01 Dec 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-118 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-119 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-120 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-121 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-122 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-123 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-124 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-125 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-126 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-127 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-128 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-129 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-130 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-131 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-132 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-133 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-134 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-135 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-136 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-156 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-216 Wed, 30 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-4 Dynamic systems, such as the protein scaffolding of human cells, can approach a fluid-like balance between assembly and disassembly with a constant input of energy. Volker Schaller et al. (pp. 19183–19188) investigated whether these dynamic systems could also achieve a frozen steady state, where the structure is fixed. The authors placed high concentrations of actin filaments, the main structural components of human cells, on a glass slide coated with motor proteins. At sufficiently high concentrations, the filaments self-organize and form moving structures that continuously assemble and disassemble. Tue, 29 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-8 This week in Lancet: COMMENT: SCIPIO brings new momentum to cardiac cell therapy. Intensified chemotherapy for diffuse large B-cell lymphomas. Rabbit ATG for aplastic anaemia treatment: a backward step?. Assessment of syndromic surveillance in Europe. WORLD REPORT: Male circumcision debate flares in the USA. Genomic future beckons for cancer management. Sat, 26 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-20 News & Analysis: Climate change: Humans Are Driving Extreme Weather; Time to Prepare. Congress and Science: First Spending Bill Giveth—And Taketh Away. Animal ecology: Global Tracking of Small Animals Gains Momentum. Embryonic stem cells: Researchers Mull Impact of Geron's Sudden Exit From Field. Fri, 25 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-12 Articles in this week: SPECIAL ARTICLE: Emergency Hospitalizations for Adverse Drug Events in Older Americans - "This national study estimated that nearly 100,000 elderly patients were hospitalized for adverse drug events annually from 2007 through 2009. Most resulted from use of common medications such as warfarin and insulin, and only 1% from medications designated as high-risk." CLINICAL PRACTICE: Screening for Prostate Cancer - "Current recommendations for prostate-specific antigen testing are reviewed, as well as the initial results of two randomized trials. The potential risks of screening, including morbidity from overdiagnosis and overtreatment, are described." Thu, 24 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-16 News and views and the next articles in this issue: Earth science: Probing the core's light elements. Interfacial chemistry: Gold's enigmatic surface. Cancer: Final act of senescence. Palaeoanthropology: The earliest modern humans in Europe. ARTICLES: The genome of Tetranychus urticae reveals herbivorous pest adaptations. Neuronal filtering of multiplexed odour representations. Thu, 24 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-39 Articles in this issue: INSIDE BLOOD: Immunodeficiency diagnosis: a Mondrian or Pollock scenario?. Stomping out barriers for hRBC mouse models. PLENARY PAPER: Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells. CLINICAL TRIALS AND OBSERVATIONS: How I treat autoimmune lymphoproliferative syndrome. Anti–Escherichia coli asparaginase antibody levels determine the activity of second-line treatment with pegylated E coli asparaginase: a retrospective analysis within the ALL-BFM trials. HEMATOPOIESIS AND STEM CELLS: AU-rich RNA binding proteins in hematopoiesis and leukemogenesis. Thu, 24 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-22 Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs (Dekódování signalizace GPCR heteromerního komplexu odhaluje sjednocený mechanismus účinku antipsychotik). Antipsychotika, jako jsou klozapin a risperidon, mají vysokou afinitu k serotoninu. Jiná non-antipsychotika, jako ritanserin, methylsergid, blokují 2AR funkci, ale chybí jim srovnatelné neuropsychologické účinky. Tato studie poskytuje pohled na antipsychotika, která mohou být součástí léčebných postupů u onemocněních jako je demence či schizofrenie. Visualization of Eukaryotic DNA Mismatch Repair Reveals Distinct Recognition and Repair Intermediates (vizualizace Mismatch opravy eukaryotické DNA odhalila výrazné neshody v úpravě meziproduktů) Single-Molecule Imaging of Transcriptionally Coupled and Uncoupled Splicing (single-molecule zobrazí transkripčně spojené i nespojené sestřihy) The Molecular Basis for the Endocytosis of Small R-SNAREs by the Clathrin Adaptor CALM (molekulární základ pro endocytózu malých R-SNAREs prostřednictvím clathrin adaptoru CALM) Wed, 23 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-153 Articles in this issue: ORIGINAL CONTRIBUTIONS: Dosing Clopidogrel Based on CYP2C19 Genotype and the Effect on Platelet Reactivity in Patients With Stable Cardiovascular Disease. Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events. Association Between Valvular Surgery and Mortality Among Patients With Infective Endocarditis Complicated by Heart Failure. MEDICAL NEWS & PERSPECTIVES: Scientists Seek Antibiotic Adjuvants. Project Aims for Better Patient Health Through Coordinating Primary Care. Risk of Blood Clots Higher for Oral Contraceptives With Certain Progestins. Wed, 23 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-217 Articles in this issue: T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex. A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands. Transmembrane Mutations in Toll-like Receptor 9 Bypass the Requirement for Ectodomain Proteolysis and Induce Fatal Inflammation. Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis. Wed, 23 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-7 This week in Lancet: WORLD REPORT: Drug withdrawal sends critical care specialists back to basics. Health 2020: WHO's missing link?. PERSPECTIVES: Saving Chile's angelitos. Moving pictures of Parkinson's disease. Sat, 19 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-19 V časopisu Science se tento týden dozvíme, že Rusko zůstává první průzkumnou misí slunečné soustavy od roku 1996 na oběžné dráze Země. Geron ukončuje svou práci na lidských kmenových buňkách (blíže se dozvíme v článku o Embryonálních kmenových buňkách získaných z lidských blastocyst). Zajímavou zprávou je, že Německo hledá nové místo pro ukládání jaderného odpadu. Fri, 18 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-11 In this week: CLINICAL THERAPEUTICS: Extracorporeal Membrane Oxygenation for ARDS in Adults - "A 41-year-old woman presents with severe pneumonia, and the acute respiratory distress syndrome (ARDS) develops. Despite mechanical ventilation, her oxygenation deteriorates. The use of extracorporeal membrane oxygenation (ECMO) is recommended." CLINICAL IMPLICATIONS OF BASIC RESEARCH: Beta-Cell Failure, Stress, and Type 2 Diabetes - "CDKAL1, a gene implicated in susceptibility to type 2 diabetes, has been found to mediate a fundamental event in protein translation that affects proinsulin processing." Thu, 17 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-15 News and views and the next articles in this issue: Ageing: Generations of longevity. Geophysics: Earth's longest fossil rift-valley system. Quantum information: The conundrum of secure positioning. Quantum physics: Shaking photons out of the vacuum. Neuroscience: Chemical ecology of pain. ARTICLES: Species-specific responses of Late Quaternary megafauna to climate and humans. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Thu, 17 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-38 Articles in this issue: INSIDE BLOOD: Gene mutation and AML pathogenesis. Angiogenesis: the HETE is on. BLOOD WORK: Basophilic stippling: a lead to the diagnosis. HOW I TREAT: How I treat pregnancy-related venous thromboembolism. CLINICAL TRIALS AND OBSERVATIONS: A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. Second induction with high-dose cytarabine and mitoxantrone: different impact on pediatric AML patients with t(8;21) and with inv(16). Thu, 17 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-154 Articles in this issue: ORIGINAL CONTRIBUTIONS: Effects of the CETP Inhibitor Evacetrapib Administered as Monotherapy or in Combination With Statins on HDL and LDL Cholesterol: A Randomized Controlled Trial. Effect of Intracoronary Delivery of Autologous Bone Marrow Mononuclear Cells 2 to 3 Weeks Following Acute Myocardial Infarction on Left Ventricular Function: The LateTIME Randomized Trial. Number of Coronary Heart Disease Risk Factors and Mortality in Patients With First Myocardial Infarction. Level of Systolic Blood Pressure Within the Normal Range and Risk of Recurrent Stroke. MEDICAL NEWS & PERSPECTIVES: Statin Therapy in Primary CVD Prevention Remains a Hot-button Topic for Some. GLOBAL HEALTH: Chagas Disease Drug Shortage. Preventing HIV in India. Wed, 16 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-3 V tomto listopadovém čísle (November 15, 2011) je hlavním tématem, jež je i na obálce časopisu, domestikace pšenice. • Tento článek s názvem Duplikace a dělení ve vývoji a funkci homologních lokusů Q pro domestikaci znaků polyploidní pšenice pojednává o genu q, který kóduje AP2 Q jako transkripční faktor, jež hraje důležitou roli v domestikaci polyploidní pšenice. Bylo hodnoceno jakou roli tyto Q/q genové sekvence hrají ve spojitosti s chromozomy A, B a D. • Další článek byl napsán na téma, o kterém jistě všichni slyšeli a to o vlně tsunami. V článku se rozebírá vliv pobřežní vegetace v roce 2004 při dopadu vlny tsunami na západní provincii Aceh (Indonésie). • Pro nás možná zajímavější články se zabývají kmenovými buňkami střeva u Drosophily, které udržují homeostázu tkáně tím, že produkují potomstvo buněk, které nahrazují umírající enterocyty a enteroendokrinní buňky nebo článek pojednávající o předefinování významu zavedených linií nádorových buněk a studium klinických mechanizmů a jejich rezistence proti rakovině. Tue, 15 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-48 In this issue: Cellular immunology and immune regulation: A Novel Combination Immunotherapy for Cancer by IL-13Rα2–Targeted DNA Vaccine and Immunotoxin in Murine Tumor Models. A Mimic of Viral Double-Stranded RNA Triggers Fulminant Type 1 Diabetes-like Syndrome in Regulatory T Cell-Deficient Autoimmune Diabetic Mouse. Induction of Immunogenic Apoptosis by Blockade of Epidermal Growth Factor Receptor Activation with a Specific Antibody. Inhibition of Autoimmune Diabetes by TLR2 Tolerance. Molecular and structural immunology: T Cell-Signaling Network Analysis Reveals Distinct Differences between CD28 and CD2 Costimulation Responses in Various Subsets and in the MAPK Pathway between Resting and Activated Regulatory T Cells. Tue, 15 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-6 This week in Lancet: WORLD REPORT: New Zealand's bold strategy for reducing health disparities. PERSPECTIVES: Bayes rules: the legacy of Thomas Bayes. William Seeley: brain explorer. COMMENT: Improvement of care in acute stroke units. Radiotherapy and survival in breast cancer. Reporting quality of life in clinical trials: a CONSORT extension. Sat, 12 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-18 News & Analysis in this issue: Enviromental science: China to Spend Billions Cleaning Up Groundwater. Atmospheric science: NSF to Turn Tank Killer Into Storm Chaser. PERSPECTIVES: Evolution: Living Fossil Younger than Thought. Material science: Toward High-Throughput Zeolite Membranes. Cell biology: Anatomy of Prostaglandin Signals. Ecology: Mosquito Trials. Fri, 11 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-21 Articles in this issue: The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells. Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes. Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits. Regulation of the Probability of Mouse Odorant Receptor Gene Choice. Fri, 11 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-10 In this week: REVIEW ARTICLES: Current Concepts: Sudden, Unexpected Death in Epilepsy - "The magnitude of the problem of sudden unexplained death in epilepsy is unrecognized in both the medical and lay communities. This review presents information on frequency, risk factors, and theories about mechanisms and recommends strategies for prevention and for patient education." Mechanisms of Disease: The Human Plasma Lipidome - "Biochemical analyses reveal that plasma contains over 600 structural forms of lipid molecules. This review summarizes known correlations between levels of lipid moieties and disease and describes potential therapeutic targets relevant to CVD, cancer, and neurologic disease." Thu, 10 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-14 News and views and the next articles in this issue: Evolutionary biology: The path to sociality. Animal behaviour: Why promiscuity pays. Planetary science: Ancient lunar dynamo. Nanotechnology: A molecular four-wheel drive. ARTICLES: Distinct stem cells contribute to mammary gland development and maintenance. Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase. Thu, 10 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-37 Articles in this issue: INSIDE BLOOD: Structural mix-n-match reveals molecular secrets of platelets. Brewing blood. REVIEW ARTICLE: Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?. BLOOD CONSULT: Blood consult: high Sokal risk chronic myeloid leukemia and suboptimal response. CLINICAL TRIALS AND OBSERVATIONS: Lack of clarity in the definition of treatment-related mortality: pediatric acute leukemia and adult acute promyelocytic leukemia as examples. GENE THERAPY: Human T cells expressing two additional receptors (TETARs) specific for HIV-1 recognize both epitopes. Thu, 10 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-155 Articles in this issue: ORIGINAL CONTRIBUTIONS: Extracranial-Intracranial Bypass Surgery for Stroke Prevention in Hemodynamic Cerebral Ischemia: The Carotid Occlusion Surgery Study Randomized Trial. Association Between Physician Billing and Cardiac Stress Testing Patterns Following Coronary Revascularization. CLINICAL REVIEW: Treatment of Brain Arteriovenous Malformations: A Systematic Review and Meta-analysis. MEDICAL NEWS & PERSPECTIVES: Public Health Cuts Threaten Preparedness, Preventive Health Services. Nobel Prize Honors Immunity Researchers. Wed, 09 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-43 In this issue: RESEARCH HIGHLIGHTS: Letting glucose take hold. USP1 keeps ID proteins stable. Catabolic effects. HOTS makes antisense. Silencing heterochromatin. PERSPECTIVES: Novel cancer immunotherapy agents with survival benefit: recent successes and next steps. Parkinson's disease and cancer: two wars, one front. Tue, 08 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-31 In this issue: Focus on Vascular Disease: "Vascular dysfunction can cause or contribute to many types of pathology, from hypertension to myocardial infarction to cancer. This series of reviews—inspired by the conference "Vascular Disease 2011: From Bench to Bedside", cosponsored by the UCSD Clinical and Translational Research Institute and Nature Medicine—highlights new mechanistic findings across a broad spectrum of vascular diseases that may lead to new and innovative treatments." Mon, 07 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-5 This week in Lancet: COMMENT: A new method of surfactant administration in preterm infants. 1608 Optimum excision margins for melanoma. A global scope for global health—including mental health. WORLD REPORT: Sound and fury after stem cell ruling. PERSPECTIVES: A requiem for the fallen from the early days of AIDS. Re-imagining disability. Sat, 05 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-32 Articles in this issue: Clinical reviews in allergy and immunology: Approaches to stepping up and stepping down care in asthmatic patients. Mechanism of allergic diseases: Using biomarkers in the assessment of airways disease. Asthma and lower airway disease: Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. The association of obesity and asthma severity and control in children. Most nocturnal asthma symptoms occur outside of exacerbations and associate with morbidity. Sat, 05 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-17 This week in the magazine: NEWS AND ANALYSIS, Bioterror research: Panel Endorses Anthrax Vaccine Study in Children. Neuroscience: The Brain's Social Network. Scientific Misconduct: Psychologist Accused of Fraud on 'Astonishing Scale'. Epidemiology: Large African TB Study Reveals Powerful Strategy to Curb Disease. NEW FOCUS, geophysics: Vigil at North Korea's Mount Doom. Fri, 04 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-23 Articles in this issue: Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy. Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients. Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions. Fri, 04 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-25 In this issue for example: NEWS AND VIEWS: More to Hi-C than meets the eye. A transposon in tb1 drove maize domestication. Putting the DNA back into DNA methylation. ANALYSIS: Probabilistic modeling of Hi-C contact maps eliminates systematic biases to characterize global chromosomal architecture. ARTICLES: Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Inverted genomic segments and complex triplication rearrangements are mediated by inverted repeats in the human genome. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Fri, 04 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-29 Articles in this issue: IMMUNOTHERAPY: Stopping monocytes in their tracks - "Therapeutic targeting of inflammatory monocyte migration attenuates disease severity." T-CELL MEMORY: The stem of T cell memory - "Identification of human T memory stem cells with increased therapeutic potential." TUMOUR IMMUNOLOGY: IFNs boost cancer killers - "Type I IFN targets CD8α+ DCs for the initiation of antitumour immunity." IMMUNE TOLERANCE: Suicide is painless - "Self-reactive T cells invade and are degraded in hepatocytes, preventing autoimmune disease." NEUROIMMUNOLOGY: Nervous ChAT - "Acetylcholine-producing T cells convey neural signals to dampen inflammation." Fri, 04 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-9 Articles in this issue: The Shortage of Essential Chemotherapy Drugs in the United States - Some essential oncology drugs are in short supply in the United States, raising concern about safety, cost, and availability of life-saving treatments. The causes are economic: manufacturers don't make big profits on generics, and oncologists make money on drug markups. Anti-Inhibitor Coagulant Complex Prophylaxis in Hemophilia with Inhibitors - In patients with hemophilia A in whom inhibitors of factor VIII develop, the prophylactic use of a factor VIII bypassing agent (anti-inhibitor coagulant complex) three times a week significantly reduced the risk of bleeding. Results of the Medicare Health Support Disease-Management Pilot Program - The Medicare Health Support Pilot Program was a study of eight commercial disease-management programs for patients with heart failure, diabetes, or both. The programs did not reduce ER visits or hospitalizations and achieved only small improvements in 14 of 40 measures. Thu, 03 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-50 Articles in this issue: INSIDE BLOOD: Time to put the CAR-T before the horse. Th1 and Th17 join forces for acute GVHD. BLOOD WORK: Polycythemia vera with pancytopenia and red cell fragmentation. PERSPECTIVES: Is heparin a placental anticoagulant in high-risk pregnancies?. CLINICAL TRIALS AND OBSERVATIONS: Addition of rituximab to chemotherapy alone as first-line therapy improves overall survival in elderly patients with mantle cell lymphoma. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Heparin and warfarin anticoagulation intensity as predictors of recurrence after deep vein thrombosis or pulmonary embolism: a population-based cohort study. Thu, 03 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-13 News and views and the next articles in this issue: Quantum computing: Diamond and silicon converge. Climate change: Man-made cyclones. Neuroscience: Periodicity without rhythmicity. Palaeontology: Fresh light on southern early mammals. Thu, 03 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-27 In this issue for example: Exome sequencing as a tool for Mendelian disease gene discovery - Exome sequencing is a powerful approach for accelerating the discovery of the genes underlying Mendelian disorders and, increasingly, of genes underlying complex traits. This Review describes the experimental and analytical options for applying exome sequencing and the key challenges in using this approach. Molecular spandrels: tests of adaptation at the genetic level - Although many studies claim to have detected an adaptive allele, this label is not always applied rigorously. The authors argue that obtaining direct evidence that specific alleles are adaptive requires approaches which functionally connect genotype, phenotype and fitness. Wed, 02 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-33 Articles in this issue: CLINICAL REVIEWS IN ALLERGY AND IMMUNOLOGY: Approaches to stepping up and stepping down care in asthmatic patients. CONTINUING MEDICAL EDUCATION EXAMINATION: Approaches to stepping up and stepping down care in asthmatic patients. ATOPIC DERMATITIS AND SKIN DISEASE: Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis. FOOD, DRUG, INSECT STING ALLERGY, AND ANAPHYLAXIS: Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen. Wed, 02 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-35 Topics and articles in this issue: CELL BIOLOGY: Proteolytic Activation Cascade of the Netherton Syndrome–Defective Protein, LEKTI, in the Epidermis: Implications for Skin Homeostasis. GENETICS: Digenic Inheritance of Mutations in the Coproporphyrinogen Oxidase and Protoporphyrinogen Oxidase Genes in a Unique Type of Porphyria. MELANOCYTES / MELANOMA: Expression and Function of the Kallikrein-Related Peptidase 6 in the Human Melanoma Microenvironment. WOUND HEALING: Erythropoietin Restores C-Fiber Function and Prevents Pressure Ulcer Formation in Diabetic Mice. Wed, 02 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-41 V měsíci listopadu se časopis Reproduction zabývá transkripční dynamikou pohlavních chromozomů, epigenetickým přeprogramováním. Je zde velice zajímavá studie o spermatogoniích, jako o potenciálním zdroji dospělých kmenových pluripotentních buněk. Další studie se zaměřuje na buňky trofoblastu a jejich funkci při implantaci a placentogenezi. Wed, 02 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-45 Articles in this issue: Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study. Monitoring of HIV viral loads, CD4 cell counts, and clinical assessments versus clinical monitoring alone for antiretroviral therapy in rural district hospitals in Cameroon (Stratall ANRS 12110/ESTHER): a randomised non-inferiority trial. Efficacy and safety of tigecycline for the treatment of infectious diseases: a meta-analysis. Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis. Wed, 02 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-49 V listopadovém čísle časopisu American Journal of Human Genetics najdeme článek o vlivu kyseliny retinové v průběhu vývoje jedince na poruchy kostí. Následující článek se zabývá pleiotropií a to studiem konkrétních SNP či genů. Je zde také mnoho článků zabývající se různými mutacemi a jejich projevy, například mutací miR-184 zodpovědná za vznik keratokonu a šedého zákalu, mutací IFT-A genu WDR19 zodpovědnou za různé druhy ciliopathie, mutací v POLR3A a POLR3B genu kódující RNA polymerázu III která může způsobit leukoencefalopathii a leukodystrofii a další. jeden z posledních článků se zabývá mutací acetylcholinového receptoru M3 způsobující poruchy močového měchýře a Prune-Belly-like syndrom. Tue, 01 Nov 2011 00:00:00 GMT http://www.medindex.cz/knihovna/odborne-casopisy/2011#m11 jurnal-47 Articles in this issue: CUTTING EDGE - Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8α+ Type. Cutting Edge: Regulatory T Cells Do Not Mediate Suppression via Programmed Cell Death Pathways. CELLULAR IMMUNOLOGY AND IMMUNE REGULATION - Elevated Tumor-Associated Antigen Expression Suppresses Variant Peptide Vaccine Responses. Sensitivity and Resistance to Regulation by IL-4 during Th17 Maturation. MOLECULAR AND STRUCTURAL IMMUNOLOGY - NKT TCR Recognition of CD1d-α-C-Galactosylceramide. Enhancement of Antibody Class-Switch Recombination by the Cumulative Activity of Four Separate Elements . Tue, 01 Nov 2011 00:00:00 GMT